Brief Report: Autistic Traits in Mothers and Children Associated with Child’s Gender Nonconformity
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We examined relationships between autistic traits in children, mothers, and fathers and gender nonconformity (GNC) in children using data from the Nurses’ Health Study II and the Growing Up Today Study 1. Autistic traits of mothers, fathers and children were measured using the Social Responsiveness Scale (SRS). GNC in children was measured using questions from the Recalled Childhood Gender Identity/Gender Role Questionnaire. In multivariable analyses increase in child’s SRS score was associated with increased odds (OR 1.35; p = 0.03) of being in a higher GNC category. Increase in maternal SRS score was also associated with increased odds (OR 1.46; p = 0.005) of the child being in a higher GNC category. Paternal SRS scores were not related to child’s GNC category.
KeywordsAutism spectrum disorder Gender Gender identity Gender nonconformity Transgender
Autism spectrum disorder
Nurses’ Health Study II
Growing Up Today Study 1
Social Responsiveness Scale
The Nurses’ Health Study II and the Growing Up Today Study are ongoing studies conducted at the Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard School of Public Health, and Harvard Medical School. The work reported in this manuscript was supported by the National Institute of Health (NIH) Grants CA50385, T32MH073124-08, P60AR047782, HD057368, and R01ES017-04, Autism Speaks Grants 1788 and 2210, the United States Department of Defense Grant W81XWH-08-1-0499, and the United States Army Medical Research and Material Command (USAMRMC) Grant A-14917. D. E. Shumer is supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, 1T32HD075727-01. S.B. Austin is supported by the Leadership Education in Adolescent Health Project, Maternal and Child Health Bureau, HRSA 6T71-MC00009.
- Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., et al. (2006). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The Special Needs and Autism Project (SNAP). Lancet, 368(9531), 210–215. doi: 10.1016/S0140-6736(06)69041-7.CrossRefPubMedGoogle Scholar
- Baron-Cohen, S. (2002). The extreme male brain theory of autism. Trends in Cognitive Sciences, 6(6), 248–254. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23180205
- Chan, Y., & Walmsley, R. P. (1997). Learning and understanding the Kruskal–Wallis one-way analysis-of-variance-by-ranks test for differences among three or more independent groups. Physical Therapy, 77(12), 1755–1762. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9413454
- Constantino, J. N., & Gruber, C. (2005). The social responsiveness scale (SRS). Los Angeles, CA: Western Psychological Services.Google Scholar
- Constantino, J. N., & Gruber, C. (2012). The social responsiveness scale: Manual. Los Angeles, CA: Western Psychological Services.Google Scholar
- Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L., et al. (2003). Validation of a brief quantitative measure of autistic traits: Comparison of the social responsiveness scale with the autism diagnostic interview-revised. Journal of Autism and Developmental Disorders, 33(4), 427–433. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12959421
- de Vries, A. L. C., Noens, I. L. J., Cohen-Kettenis, P. T., van Berckelaer-Onnes, I. A., & Doreleijers, T. A. (2010). Autism spectrum disorders in gender dysphoric children and adolescents. Journal of Autism and Developmental Disorders, 40(8), 930–936. doi: 10.1007/s10803-010-0935-9.CrossRefPubMedCentralPubMedGoogle Scholar
- Field, A. E., Camargo, C. A., Taylor, C. B., Berkey, C. S., Frazier, A. L., Gillman, M. W., et al. (1999). Overweight, weight concerns, and bulimic behaviors among girls and boys. Journal of the American Academy of Child and Adolescent Psychiatry, 38(6), 754–760. doi: 10.1097/00004583-199906000-00024.CrossRefPubMedGoogle Scholar
- Knickmeyer, R., Baron-Cohen, S., Fane, B. A., Wheelwright, S., Mathews, G. A., Conway, G. S., et al. (2006). Androgens and autistic traits: A study of individuals with congenital adrenal hyperplasia. Hormones and Behavior, 50(1), 148–153. doi: 10.1016/j.yhbeh.2006.02.006.CrossRefPubMedGoogle Scholar
- Landén, M., & Rasmussen, P. (1997). Gender identity disorder in a girl with autism—a case report. European Child & Adolescent Psychiatry, 6(3), 170–173. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9383652
- Lyall, K., Constantino, J., Weisskopf, M., Roberts, A., Ascherio, A., & Santangelo, S. (2014). Parental social responsiveness and risk of autism spectrum disorder in offspring. JAMA - Psychiatry, 71(8), 936–942.Google Scholar
- Mukaddes, N. (2002). Gender identity problems in autistic children. Child: Care, Health and Development, 28(6), 529–532.Google Scholar
- Roberts, A. L., Rosario, M., Slopen, N., Calzo, J., & Austin, S. B. (2013). Childhood gender nonconformity, bullying victimization, and depressive symptoms across adolescence and early adulthood: An 11-year longitudinal study. Journal of the American Academy of Child and Adolescent Psychiatry, 52(2), 143–152.CrossRefPubMedCentralPubMedGoogle Scholar
- Schoppe-Sullivan, S. J., Kotila, L., Jia, R., Lang, S. N., & Bower, D. J. (2013). Comparisons of levels and predictors of mothers’ and fathers’ engagement with their preschool aged children. Early Child Development and Care, 183(3–4), 498–514. doi: 10.1080/03004430.2012.711596.CrossRefPubMedCentralPubMedGoogle Scholar
- Strang, J. F., Kenworthy, L., Dominska, A., Sokoloff, J., Kenealy, L. E., Berl, M., et al. (2014). Increased gender variance in autism spectrum disorders and attention deficit hyperactivity disorder. Archives of Sexual Behavior. doi: 10.1007/s10508-014-0285-3.
- Voracek, M. (2010). Fetal androgens and autism. The British Journal of Psychiatry: The Journal of Mental Science, 196(5), 416; author reply 416–417. doi: 10.1192/bjp.196.5.416.