New Interview and Observation Measures of the Broader Autism Phenotype: Group Differentiation
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To identify the broader autism phenotype (BAP), the Family History Interview subject and informant versions and an observational tool (Impression of Interviewee), were developed. This study investigated whether the instruments differentiated between parents of children with autism, and parents of children with Down syndrome (DS). The BAP scores of parents of 28 multiplex autism families were compared with parents from, 32 DS families. The BAP measures provided good group differentiation but when considered together, the subject interview did not improve group differentiation. The differentiation was better for fathers than mothers. The measures do carry an important degree of validity; whether they can differentiate the BAP from other social disorders should be tested.
KeywordsBroader autism phenotype Group differentiation Interview measures Observational measures Diagnosis
We are grateful to: participating families, Dutch ASD Parent Association, Dutch Down Syndrome Association, Ms. Scherpenisse and Ms. Steggehuis for data collection. This work was supported in part by the Janusz Korczack Foundation. Funders had no role in study design, data collection, analysis, manuscript preparation/publication. The IMGSAC are grateful for project grants from: The Medical Research Council, The Wellcome Trust, The Nancy Lurie Marks Family Foundation (GR071470MA), BIOMED 2 (CT-97-2759), EC Fifth Framework (QLG2-CT-1999-0094), Telethon—Italy (GGP030227), Beatrice Surovell Haskells Fond for Child Mental Health Research of Copenhagen and the Danish Natural Science Research Council (9802210), Fondazione Cassa di Risparmio di Bologna, Deutsche Forschungsgemeinschaft, Fondation France Telecom, Conseil Regional Midi-Pyrenees, Danish Medical Research Council, Sofiefonden.
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