Excess Mortality and Causes of Death in Autism Spectrum Disorders: A Follow up of the 1980s Utah/UCLA Autism Epidemiologic Study
- 1k Downloads
This study’s purpose was to investigate mortality among individuals with autism spectrum disorders (ASD) ascertained during a 1980s statewide autism prevalence study (n = 305) in relation to controls. Twenty-nine of these individuals (9.5 %) died by the time of follow up, representing a hazard rate ratio of 9.9 (95 % CI 5.7–17.2) in relation to population controls. Death certificates identified respiratory, cardiac, and epileptic events as the most common causes of death. The elevated mortality risk associated with ASD in the study cohort appeared related to the presence of comorbid medical conditions and intellectual disability rather than ASD itself suggesting the importance of coordinated medical care for this high risk sub-population of individuals with ASD.
KeywordsAutism spectrum disorders Mortality Causes of death Epilepsy Intellectual disability
This research was supported by Autism Speaks Grant #5955. We thank the Pedigree and Population Resource (funded by the Huntsman Cancer Foundation) for its role in the ongoing collection, maintenance, and support of the Utah Population Database (UPDB).
- Baird, P. A., & Sadovnick, A. D. (1990). Underlying causes of death in Down syndrome: Accuracy of British Columbia death certificate data. Canadian Journal of Public Health, 81(6), 456–461.Google Scholar
- CIA World Factbook. (2011a). Sweden death rate. Retrieved from http://www.cia.gov.
- CIA World Factbook. (2011b). United States death rate. Retrieved from http://www.cia.gov.
- Centers for Disease Control and Prevention. (2009). Prevalence of autism spectrum disorders—Autism and developmental disabilities monitoring network, United States, 2006. Morbidity and Mortality Weekly Report, 58(10), 1–20.Google Scholar
- Miller, J. S., Bilder, D., Farley, M., Coon, H., Pinborough-Zimmerman, J., Jenson, W., et al. (2012). Autism spectrum disorder reclassified: A second look at the 1980’s Utah/UCLA Autism Epidemiologic Study. Journal of Autism and Developmental Disorders. doi: 10.1007/s10803-012-1566-0.
- Pinborough-Zimmerman, J., Bakian, A., Fombonne, E., Bilder, D., Taylor, J., & McMahon, W. M. (2012). Changes in the administrative prevalence of autism spectrum disorders: Contribution of special education and health data from 2002–2008. Journal of Autism and Developmental Disorders, 42, 521–530.Google Scholar
- Utah Department of Health. (2005). Utah health status update: Adjusting Utah’s state health ranking for age [PDF]. Retrieved from http://health.utah.gov.
- Van Naarden Braun, K., Pettygrove, S., Daniels, J., Miller, L., Nicholas, J., Baio, J., et al. (2007). Evaluation of a methodology for a collaborative multiple source surveillance network for autism spectrum disorders–Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2002. Surveillance Summaries: Morbidity and Mortality Weekly Report, 56(1), 29–40.Google Scholar