Journal of Autism and Developmental Disorders

, Volume 42, Issue 11, pp 2285–2296 | Cite as

Comparison of Children with Autism Spectrum Disorder with and Without Schizophrenia Spectrum Traits: Gender, Season of Birth, and Mental Health Risk Factors

  • Kenneth D. Gadow
  • Carla J. DeVincent
Original Paper


Children with autism spectrum disorder (ASD) with and without co-occurring schizophrenia spectrum traits (SST) were examined for differences in co-occurring psychiatric symptoms, background characteristics, and mental health risk factors. Participating mothers and teachers completed a DSM-IV-referenced rating scale and a background questionnaire (mothers only) describing 147 children (6–12 years) with ASD. There was a clear pattern of group differences in co-occurring psychiatric symptom severity (+SST > SST−) and background characteristics. Children with impairing SST had more mental health risk factors. Girls were more likely to be classified SST according to mothers’ ratings. Children born in spring–summer were more likely to be classified non-SST by teachers’ ratings. Findings provide tentative evidence that SST may be a useful marker of behavioral heterogeneity within the ASD clinical phenotype.


Autism spectrum disorder Schizophrenia spectrum disorder Season of birth Gender 



Dr. Gadow is with the Department of Psychiatry and Behavioral Sciences, Stony Brook University, Stony Brook, NY; Dr. DeVincent is with the Department of Radiology, Stony Brook University, Stony Brook, NY. This study was supported, in part, by the Matt and Debra Cody Center for Autism and Developmental Disorders. The authors wish to thank Dr. John Pomeroy for supervising the ASD diagnoses, and three anonymous reviewers for providing very helpful comments on an earlier version of this paper.


  1. Achenbach, T. M. (1991). Manual for the Child Behavior Checklist/4-18 and 1991 Profile. Burlington: University of Vermont, Department of Psychiatry.Google Scholar
  2. Badcock, C. (2011). The imprinted brain: How genes set the balance between autism and psychosis. Epigenomics, 3, 345–359.PubMedCrossRefGoogle Scholar
  3. Barneveld, P. S., Pieterse, J., de Sonneville, L., van Rijn, S., Lahuis, B., van Engeland, H., et al. (2011). Overlap of autistic and schizotypal traits in adolescents with autism spectrum disorders. Schizophrenia Research, 126, 231–236.PubMedCrossRefGoogle Scholar
  4. Baron-Cohen, S., Lombardo, M. V., Auyeung, B., Ashwin, E., Chakrabarti, B., & Knickmeyer, R. (2011). Why are autism spectrum conditions more prevalent in males? PLoS Biology, 9, e1001081.PubMedCrossRefGoogle Scholar
  5. Bloss, C. S., & Courchesne, E. (2007). MRI neuroanatomy in young girls with autism: A preliminary study. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 515523.CrossRefGoogle Scholar
  6. Bolton, P., Pickles, A., Harrington, R., Macdonald, H., & Rutter, M. (1992). Season of birth: Issues, approaches and findings for autism. Journal of Child Psychology and Psychiatry, 33, 509–530.PubMedCrossRefGoogle Scholar
  7. Bolton, P. F., Pickles, A., Murphy, M., & Rutter, M. (1998). Autism, affective, and other psychiatric disorders: Patterns of familial aggregation. Psychological Medicine, 28, 385–395.PubMedCrossRefGoogle Scholar
  8. Breetvelt, E. J., Boks, M. P. M., Numans, M. E., Selten, J. P., Sommer, I. E. C., Grobbee, D. E., et al. (2010). Schizophrenia risk factors constitute general risk factors for psychiatric symptoms in the population. Schizophrenia Research, 120, 184–190.PubMedCrossRefGoogle Scholar
  9. Brosnan, M., Ashwin, C., Walker, I., & Donaghue, J. (2010). Can an “extreme female brain” be characterized in terms of psychosis? Personality and Individual Differences, 49, 738–742.CrossRefGoogle Scholar
  10. Brown, A. S. (2011). The environment and susceptibility to schizophrenia. Progress in Neurobiology, 93, 23–58.PubMedCrossRefGoogle Scholar
  11. Cheung, C., Yu, K., Fung, G., Leung, M., Wong, C., Li, Q., et al. (2010). Autistic disorders and schizophrenia: Related or remote? An anatomical likelihood estimation. PLoS ONE, 5, e12233.PubMedCrossRefGoogle Scholar
  12. Chou, K. H., Cheng, Y., Chen, I. Y., Lin, C. P., & Chu, W. C. (2011). Sex-linked white matter microstructure of the social and analytic brain. NeuroImage, 54, 725–733.PubMedCrossRefGoogle Scholar
  13. Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Mahwah: Lawrence Erlbaum.Google Scholar
  14. Cohen, J. (1994). The earth is round (p < .05). American Psychologist, 49, 997–1003.Google Scholar
  15. Cohen, I. L., Liu, X., Schultz, C., White, B. N., Jenkins, E. C., Brown, W. T., et al. (2003). Association of autism severity with a monoamine oxidase A functional polymorphism. Clinical Genetics, 64, 190–197.PubMedCrossRefGoogle Scholar
  16. Comi, A. M., Zimmerman, A. W., Frye, V. H., Law, P. A., & Peeden, J. N. (1999). Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. Journal of Child Neurology, 14, 388–394.PubMedCrossRefGoogle Scholar
  17. Cooper, S. A., Smiley, E., Morrison, J., Allan, L., Williamson, A., Finlayson, J., et al. (2007). Psychosis and adults with intellectual disabilities. Social Psychiatry and Psychiatric Epidemiology, 42, 530–536.PubMedCrossRefGoogle Scholar
  18. Crespi, B., & Badcock, C. (2008). Psychosis and autism as diametrical disorders of the social brain. Behavioral and Brain Sciences, 31, 241–261; discussion 261–320.Google Scholar
  19. Crespi, B. J., & Thiselton, D. L. (2011). Comparative immunogenetics of autism and schizophrenia. Genes, Brain and Behavior, 10, 689–701.CrossRefGoogle Scholar
  20. Crespi, B., Stead, P., & Elliot, M. (2010). Comparative genomics of autism and schizophrenia. Proceedings of the National Academy of Sciences, 107(suppl. 1), 1736–1741.CrossRefGoogle Scholar
  21. Curtis, J. T., Hood, A. N., Chen, Y., Cobb, G. P., & Wallace, D. R. (2010). Chronic metals ingestion by prairie voles produces sex-specific deficits in social behavior: An animal model of autism. Behavioural Brain Research, 213, 42–49.PubMedCrossRefGoogle Scholar
  22. Dean, K., Stevens, H., Mortensen, P. B., Murray, R. M., Walsh, E., & Pedersen, C. B. (2010). Full spectrum of psychiatric outcomes among offspring with parental history of mental disorder. Archives of General Psychiatry, 67, 822–829.PubMedCrossRefGoogle Scholar
  23. Debbané, M., Van der Linden, M., Gex-Fabry, M., & Eliez, S. (2009). Cognitive and emotional associations to positive schizotypy during adolescence. Journal of Child Psychology and Psychiatry, 50, 326–334.PubMedCrossRefGoogle Scholar
  24. DeVincent, C. J., & Gadow, K. D. (2009). Relative clinical utility of three child symptom inventory-4 scoring algorithms for differentiating children with autism spectrum disorder versus attention-deficit hyperactivity disorder. Autism Research, 2, 312–321.PubMedGoogle Scholar
  25. Drabick, D. A., & Gadow, K. D. (2012). Deconstructing the oppositional defiant disorder phenotype: Clinic-based evidence for an anger/irritability phenotype. Journal of the American Academy of Child and Adolescent Psychiatry,. doi: 10.1016/j.jaac.2012.01.010.
  26. Eisenberg, D. T. A., Campbell, B., Mackillop, J., Lum, J. K., & David, S. (2007). Season of birth and dopamine receptor gene associations with impulsivity, sensation seeking and reproductive behaviors. PLoS One, 2, e1216.PubMedCrossRefGoogle Scholar
  27. Ericson, M., Tuvblad, C., Raine, A., Young-Wolff, K., & Baker, L. A. (2011). Heritability and longitudinal stability of schizotypal traits during adolescence. Behavior Genetics, 41, 499–511.PubMedCrossRefGoogle Scholar
  28. Faridi, K., Pawliuk, N., King, S., Joober, R., & Malla, A. K. (2009). Prevalence of psychotic and non-psychotic disorders in relatives of patients with a first episode psychosis. Schizophrenia Research, 114, 57–63.PubMedCrossRefGoogle Scholar
  29. Fletcher, D., Loschen, E., & Stavrakaki, C. (Eds.). (2007). Diagnostic manual-intellectual disability: A textbook of diagnosis of mental disorders in persons with intellectual disability. New York: National Association for the Dually Diagnosed.Google Scholar
  30. Freeman, D., & Fowler, D. (2009). Routes to psychotic symptoms: Trauma, anxiety and psychosis-like experiences. Psychiatry Research, 169, 107–112.PubMedCrossRefGoogle Scholar
  31. Fresan, A., Camarena, B., Apiquian, R., Aguilar, A., Urraca, N., & Nicolini, H. (2007). Association study of MAO-a and DRD4 genes is schizophrenic patients with aggressive behavior. Neuropsychobiology, 55, 171–175.PubMedCrossRefGoogle Scholar
  32. Gadow, K. D. (2012a). Group differences in schizophrenia spectrum symptoms in children with autism spectrum disorder versus clinic controls with and without co-occurring ADHD. (manuscript in preparation).Google Scholar
  33. Gadow, K. D. (2012b). Association of schizophrenia spectrum symptoms with severity of autism spectrum disorder (ASD) in children with ASD and clinic controls. (manuscript in preparation).Google Scholar
  34. Gadow, K. D., DeVincent, C. J., Olvet, D. M., Pisarevskaya, V., & Hatchwell, E. (2010). Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder, and repetitive behaviors in children with autism spectrum disorder. European Journal of Neuroscience, 32, 1058–1065.PubMedCrossRefGoogle Scholar
  35. Gadow, K. D., DeVincent, C. J., Pomeroy, J., & Azizian, A. (2005). Comparison of DSM-IV symptoms in elementary school-aged children with PDD versus clinic and community samples. Autism, 9, 392–415.PubMedCrossRefGoogle Scholar
  36. Gadow, K. D., DeVincent, C., & Schneider, J. (2008a). Predictors of psychiatric symptoms in children with an autism spectrum disorder. Journal of Autism and Developmental Disorders, 38, 1710–1720.PubMedCrossRefGoogle Scholar
  37. Gadow, K. D., & Drabick, D. A. G. (2012). Symptoms of autism and schizophrenia spectrum disorders in clinically referred youth with oppositional defiant disorder. Research in Developmental Disabilities,. doi: 10.1016/j.ridd.2012.01.004.PubMedGoogle Scholar
  38. Gadow, K. D., Drabick, D. A. G., Loney, J., Sprafkin, J., Salisbury, H., Azizian, A., et al. (2004). Comparison of ADHD symptom subtypes as source-specific syndromes. Journal of Child Psychology and Psychiatry, 45, 1135–1149.PubMedCrossRefGoogle Scholar
  39. Gadow, K. D., Guttmann-Steinmetz, S., Rieffe, C., & DeVincent, C. J. (2011). Depression symptoms in boys with autism spectrum disorder and comparison samples. Journal of Autism and Developmental Disorders,. doi: 10.1007/s10803-011-1367-x.
  40. Gadow, K. D., Schwartz, J., DeVincent, C., Strong, G., & Cuva, S. (2008b). Clinical utility of autism spectrum disorder scoring algorithms for the child symptom inventory. Journal of Autism and Developmental Disorders, 38, 419–427.PubMedCrossRefGoogle Scholar
  41. Gadow, K. D., & Sprafkin, J. (1986). Stony Brook Child Psychiatric Checklist-3. Stony Brook: State University of New York, Department of Psychiatry.Google Scholar
  42. Gadow, K. D., & Sprafkin, J. (1995). Adolescent supplement to the child symptom inventories manual. Stony Brook: Checkmate Plus.Google Scholar
  43. Gadow, K. D., & Sprafkin, J. (2002). Child symptom inventory-4 screening and norms manual. Stony Brook: Checkmate Plus.Google Scholar
  44. Gadow, K. D., & Sprafkin, J. (2005). Child and adolescent symptom inventory-4R. Stony Brook: Checkmate Plus.Google Scholar
  45. Gadow, K. D., & Sprafkin, J. (2008). Adolescent symptom inventory-4 screening and norms manual. Stony Brook: Checkmate Plus.Google Scholar
  46. Gadow, K. D., & Sprafkin J. (2010). The symptom inventories: An annotated bibliography [On-line]. Checkmate Plus: Stony Brook, NY. Available:
  47. Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal risk factors for autism: Comprehensive meta-analysis. British Journal of Psychiatry, 195, 7–14.PubMedCrossRefGoogle Scholar
  48. Gauthier, J., Champagne, N., Lafrenière, R. G., Xiong, L., Spiegelman, D., Brustein, E., et al. (2010). De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. PNAS, 107, 7863–7868.PubMedCrossRefGoogle Scholar
  49. Girirajan, S., Rosenfeld, J. A., Cooper, G. M., Antonacci, F., Siswara, P., Itsara, A., et al. (2010). A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay. Nature Genetics, 42, 203–210.PubMedCrossRefGoogle Scholar
  50. Grayson, P., & Carlson, G. A. (1991). The utility of a DSM-III-R-based checklist in screening child psychiatric patients. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 669–673.PubMedCrossRefGoogle Scholar
  51. Guilmatre, A., Dubourg, C., Mosca, A. L., Legallic, S., Goldenberg, A., Drouin-Garraud, V., et al. (2009). Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. Archives of General Psychiatry, 66, 947–956.PubMedCrossRefGoogle Scholar
  52. Gurney, J. G., McPheeters, M. L., & Davis, M. M. (2006). Parental report of health conditions and health care use among children with and without autism. Archives of Pediatric and Adolescent Medicine, 160, 825–830.CrossRefGoogle Scholar
  53. Guttmann-Steinmetz, S., Gadow, K. D., DeVincent, C. J., & Crowell, J. (2010). Anxiety symptoms in boys with autism spectrum disorder, attention-deficit hyperactivity disorder, or chronic multiple tic disorder and community controls. Journal of Autism and Developmental Disorders, 40, 1006–1016.PubMedCrossRefGoogle Scholar
  54. Herbert, K. J., Miller, L. L., & Joinson, C. J. (2010). Association of autism spectrum disorder with season of birth and conception in a UK cohort. Autism Research, 3, 185–190.CrossRefGoogle Scholar
  55. Hollingshead, A. B. (1975). Four factor index of social status. New Haven: Department of Sociology, Yale University.Google Scholar
  56. Holtmann, M., Bölte, S., & Poustka, F. (2007). Autism spectrum disorders: Sex differences in autistic behaviour domains and coexisting psychopathology. Developmental Medicine and Child Neurology, 49, 361–366.PubMedCrossRefGoogle Scholar
  57. Hurst, R. M., Nelson-Gray, R. O., Mitchell, J. T., & Kwapil, T. R. (2007). The relationship of Asperger’s characteristics and schizotypal personality traits in a non-clinical adult sample. Journal of Autism and Developmental Disorders, 37, 1711–1720.PubMedCrossRefGoogle Scholar
  58. Jessen, H. M., & Auger, A. P. (2011). Sex differences in epigenetic mechanisms may underlie risk and resilience for mental disorders. Epigenetics, 6, 857–861.PubMedCrossRefGoogle Scholar
  59. King, B. H., & Lord, C. (2011). Is schizophrenia on the autism spectrum? Brain Research, 1380, 34–41.PubMedCrossRefGoogle Scholar
  60. Kirov, G., Gumus, D., Chen, W., Norton, N., Georgieva, L., Sari, M., et al. (2008). Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Human Molecular Genetics, 17, 458–465.PubMedCrossRefGoogle Scholar
  61. Knobel, K. A. B., & Sanchez, T. G. (2009). Selective auditory attention and silence elicit auditory hallucination in a nonclinical sample. Cognitive Neuropsychiatry, 14, 1–10.PubMedCrossRefGoogle Scholar
  62. Lecavalier, L., Gadow, K. D., DeVincent, C. J., Houts, C., & Edwards, M. C. (2009). Deconstructing the PDD clinical phenotype: Internal validity of the DSM-IV. Journal of Child Psychology and Psychiatry, 50, 1246–1254.PubMedCrossRefGoogle Scholar
  63. Lee, L. C., Newschaffer, C. J., Lessler, J. T., Lee, B. K., Shah, R., & Zimmerman, A. W. (2008). Variation in season of birth in singleton and multiple births concordant for autism spectrum disorder. Pediatric and Perinatal Epidemiology, 22, 172–179.PubMedCrossRefGoogle Scholar
  64. Longenecker, J., Genderson, J., Dickinson, D., Malley, J., Elvevåg, B., Weinberger, D. R., et al. (2010). Where have all the women gone? Participant gender in epidemiological and nonepidemiological research of schizophrenia. Schizophrenia Research, 119, 240–245.PubMedCrossRefGoogle Scholar
  65. Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.PubMedCrossRefGoogle Scholar
  66. Maimburg, R. D., Bech, B. H., Vaeth, M., Møller-Madsen, B., & Olsen, J. (2010). Neonatal jaundice, autism, and other disorders of psychological development. Pediatrics, 126, 872–878.PubMedCrossRefGoogle Scholar
  67. Margo, A., Hemsley, D. R., & Slade, P. D. (1981). The effects of varying auditory input on schizophrenic hallucinations. British Journal of Psychiatry, 139, 122–127.PubMedCrossRefGoogle Scholar
  68. Mata, I., Sham, P. C., Gilvarry, C. M., Jones, P. B., Lewis, S. W., & Murray, R. M. (2000). Childhood schizotypy and positive symptoms in schizophrenic patients predict schizotypy in relatives. Schizophrenia Research, 44, 129–136.PubMedCrossRefGoogle Scholar
  69. Mattison, R. E., Gadow, K. D., Sprafkin, J., Nolan, E. E., & Schneider, J. (2003). A DSM-IV-referenced teacher rating scale for use in clinical management. Journal of the American Academy of Child and Adolescent Psychiatry, 42, 444–449.CrossRefGoogle Scholar
  70. Meyer, U., Feldon, J., & Mammann, O. (2011). Schizophrenia and autism: Both shared and disorder-specific pathogenesis via perinatal inflammation? Pediatric Research, 69 (5, Pt. 2), 26R–33R.Google Scholar
  71. Mittal, V. A., Ellman, L. M., & Cannon, T. D. (2008). Gene-environment interaction and covariation in schizophrenia: The role of obstetric complications. Schizophrenia Bulletin, 34, 1083–1094.PubMedCrossRefGoogle Scholar
  72. Nayani, T. N., & David, A. S. (1996). The auditory hallucination: A phenomenological survey. Psychological Medicine, 26, 177–189.PubMedCrossRefGoogle Scholar
  73. Offord, D. R., Boyle, M. H., Racine, Y., Szatmari, P., Fleming, J. E., Sanford, M., et al. (1996). Integrating assessment data from multiple informants. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1078–1085.PubMedCrossRefGoogle Scholar
  74. Padgett, F. E., Miltsiou, E., & Tiffin, P. A. (2010). The co-occurrence of nonaffective psychosis and the pervasive developmental disorders: A systematic review. Journal of Intellectual & Developmental Disability, 35, 187–198.CrossRefGoogle Scholar
  75. Pfaff, D. W., Rapin, I., & Goldman, S. (2011). Male predominance in autism: Neuroscience influences on arousal and social anxiety. Autism Research, 4, 163–176.PubMedCrossRefGoogle Scholar
  76. Piven, J., & Palmer, P. (1999). Psychiatric disorder and the broad autism phenotype: Evidence from a family study of multiple-incidence autism families. American Journal of Psychiatry, 156, 557–563.PubMedGoogle Scholar
  77. Qiao, Y., Riendeau, N., Koochek, M., Liu, X., Harvard, C., Hildebrand, M. J., et al. (2009). Phenomic determinants of genomic variation in autism spectrum disorders. Journal of Medical Genetics, 46, 680–688.PubMedCrossRefGoogle Scholar
  78. Rapoport, J., Chavez, A., Greenstein, D., Addington, A., & Gogtay, N. (2009). Autism spectrum disorders and childhood-onset schizophrenia: Clinical and biological contributions to a relation revisited. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 10–18.Google Scholar
  79. Ronald, A., Larsson, H., Anckarsäter, H., & Lichtenstein, P. (2011). A twin study of autism symptoms in Sweden. Molecular Psychiatry, 16, 1039–1047.PubMedCrossRefGoogle Scholar
  80. Roohi, J., DeVincent, C. J., Hatchwell, E., & Gadow, K. D. (2009). Association of a monoamine oxidase-A gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 67–74.PubMedCrossRefGoogle Scholar
  81. Rothman, K. (1990). No adjustments are needed for multiple comparisons. Epidemiology, 1, 43–46.PubMedCrossRefGoogle Scholar
  82. Roussos, P., Giakoumaki, S. G., & Bitsios, P. (2010). Cognitive and emotional processing associated with the season of birth and dopamine D4 receptor gene. Neurobiology, 48, 3926–3933.Google Scholar
  83. Russell-Smith, S. N., Maybery, M. T., & Bayliss, D. M. (2010). Are the autism and positive schizotypy spectra diametrically opposed in local versus global processing? Journal of Autism and Developmental Disorders, 40, 968–977.PubMedCrossRefGoogle Scholar
  84. Sarachana, T., Xu, M., Wu, R. C., & Hu, V. W. (2011). Sex hormones in autism: Androgens and extrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism. PLoS ONE, 6, e17116.PubMedCrossRefGoogle Scholar
  85. Sebat, J., Levy, D. L., & McCarthy, S. E. (2009). Rare structural variants in schizophrenia: One disorder, multiple mutations; one mutation, multiple disorders. Trends in Genetics, 25, 528–535.PubMedCrossRefGoogle Scholar
  86. Skuse, D. H. (2007). Rethinking the nature of genetic vulnerability of autistic spectrum disorders. Trends in Genetics, 23, 387–395.PubMedCrossRefGoogle Scholar
  87. Sorensen, H. J., Mortensen, E. L., Schiffman, J., Ekstrom, M., Denenney, D., & Mednick, S. A. (2010). Premorbid IQ and adult schizophrenia spectrum disorder: Verbal performance subtests. Psychiatry Research, 178, 23–26.PubMedCrossRefGoogle Scholar
  88. Sporn, A. L., Addington, A. M., Gogtay, N., Ordoñez, A. E., Gornick, M., Clasen, L., et al. (2004). Pervasive developmental disorder and childhood-onset schizophrenia: Comorbid disorder or a phenotypic variant of a very early onset illness. Biological Psychiatry, 55, 989–994.PubMedCrossRefGoogle Scholar
  89. Starling, J., & Dossetor, D. (2009). Pervasive developmental disorders and psychosis. Current Psychiatry Reports, 11, 190–196.PubMedCrossRefGoogle Scholar
  90. Sugranyes, G., Kyriakopoulos, M., Corrigall, R., Taylor, E., & Frangou, S. (2011). Autism spectrum disorders and schizophrenia: Meta-analysis of the neural correlates of social cognition. PLoS ONE, 6, e25322.PubMedCrossRefGoogle Scholar
  91. Tarrier, N. (1987). An investigation of residual psychotic symptoms in discharged schizophrenic patients. British Journal of Clinical Psychology, 26, 141–143.PubMedCrossRefGoogle Scholar
  92. Van der Gaag, R. J., Buitelaar, J., Van den Ban, E., Bezemer, M., Mijio, L., & Van Engeland, H. (1995). A controlled multivariate chart review of multiple complex developmental disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 1096–1106.PubMedCrossRefGoogle Scholar
  93. van Os, J., Linscott, R. J., Myin-Germeys, I., Delespaul, P., & Krabbendam, L. (2009). A systematic review and meta-analysis of the psychosis continuum: Evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychological Medicine, 39, 179–195.PubMedGoogle Scholar
  94. Verdoux, H., Husky, M., Tournier, M., Sorbara, F., & Swendsen, J. D. (2003). Social environments and daily life occurrence of psychotic symptoms. Social Psychiatry and Psychiatric Epidemiology, 38, 654–661.PubMedCrossRefGoogle Scholar
  95. Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., et al. (2008). Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science, 320, 539–543.PubMedCrossRefGoogle Scholar
  96. Weisbrot, D. M., Gadow, K. D., DeVincent, C. J., & Pomeroy, J. (2005). The presentation of anxiety in children with pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology, 15, 477–496.PubMedCrossRefGoogle Scholar
  97. White, S. W., Oswald, D., Ollendick, T., & Scahill, L. (2009). Anxiety in children and adolescents with autism spectrum disorders. Clinical Psychology Review, 29, 216–229.PubMedCrossRefGoogle Scholar
  98. Yirmiya, N., & Shaked, M. (2005). Psychiatric disorders in parents of children with autism. A meta-analysis. Journal of Child Psychology and Psychiatry, 46, 69–83.PubMedCrossRefGoogle Scholar
  99. Zwaigenbaum, L., Szatmari, P., Jones, M. B., Bryson, S. E., MacLean, J. E., Mahoney, W. J., et al. (2002). Pregnancy and birth complications in autism and liability to the broader autism phenotype. Journal of the American Academy of Child and Adolescent Psychiatry, 41, 572–579.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Psychiatry and Behavioral Science, Cody Center for Autism and Developmental Disabilities (Pediatrics)Stony Brook UniversityStony BrookUSA
  2. 2.Department of RadiologyStony Brook UniversityStony BrookUSA

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