Social and Non-Social Cueing of Visuospatial Attention in Autism and Typical Development
- 784 Downloads
Three experiments explored attention to eye gaze, which is incompletely understood in typical development and is hypothesized to be disrupted in autism. Experiment 1 (n = 26 typical adults) involved covert orienting to box, arrow, and gaze cues at two probabilities and cue-target times to test whether reorienting for gaze is endogenous, exogenous, or unique; experiment 2 (total n = 80: male and female children and adults) studied age and sex effects on gaze cueing. Gaze cueing appears endogenous and may strengthen in typical development. Experiment 3 tested exogenous, endogenous, and gaze-based orienting in 25 typical and 27 Autistic Spectrum Disorder (ASD) children. ASD children made more saccades, slowing their reaction times; however, exogenous and endogenous orienting, including gaze cueing, appear intact in ASD.
KeywordsGaze Box Arrow Vision Oculomotor Child
We thank all of the families who generously participated in this study. We thank Maggie M. Gross for study coordination and clinical assessments, Ansley Stanfill for technical support, Fran Miezin for computer engineering, and Patricia LaVesser for clinical assessments. Subjects were recruited with the assistance of the Interactive Autism Network (IAN) Research Database at the Kennedy Krieger Institute and Johns Hopkins Medicine—Baltimore, sponsored by the Autism Speaks Foundation. We thank the Washington University School of Medicine Volunteers for Health (VFH) program; Autism Speaks; Missouri Families for Effective Autism Treatment (MO-FEAT); the Illinois Center for Autism; and other local research laboratories, clinics, schools, and community doctors’ offices for their help in advertising the studies. Research funding included: R21 MH079958, K12 EY16336, T32 DA07261 (John Pruett); The Blanch F. Ittleson Endowment Fund (Richard Todd); McDonnell Center for Higher Brain Function grant “Cueing visual-spatial attention with biologically-relevant versus non-biological stimuli in children and adults with and without autism” (Steve Petersen).
Conflict of Interest Statement
Drs. Pruett and Petersen report no biomedical financial interest or potential conflicts of interest. Dr. Todd is deceased but had no biomedical financial interest or potential conflicts of interest. Dr. Constantino receives royalties on the Social Responsiveness Scale, which is published and distributed by Western Psychological Services. Ms. LaMacchia, Ms. Hoertel, Ms. Squire, and Ms. McVey report no biomedical financial interest or potential conflicts of interest.
- Achenbach, T. (2001). CBLC/6-18 profile for boys—syndrome scales. ASEBA.Google Scholar
- Achenbach, T. (2003). Adult behavior checklist for ages 18–59. ASEBA.Google Scholar
- American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed. Text Revision). Washington, DC: American Psychiatric Association.Google Scholar
- Bayliss, A. P., di Pellegrino, G., & Tipper, S. P. (2005). Sex differences in eye gaze and symbolic cueing of attention. Quarterly Journal of Experimental Psychology A, 58(4), 631–650.Google Scholar
- Collie, A., Maruff, P., Yucel, M., Danckert, J., & Currie, J. (2000). Spatiotemporal distribution of facilitation and inhibition of return arising from the reflexive orienting of covert attention. Journal of Experimental Psychology: Human Perception and Performance, 26(6), 1733–1745.PubMedCrossRefGoogle Scholar
- Constantino, J. N. (2002). The social responsiveness scale. Los Angeles: Western Psychological Services.Google Scholar
- Cornish, K. M., Manly, T., Savage, R., Swanson, J., Morisano, D., Butler, N., et al. (2005). Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample. Molecular Psychiatry, 10(7), 686–698.PubMedCrossRefGoogle Scholar
- Howlin, P., Magiati, I., & Charman, T. (2009). Systematic review of early intensive behavioral interventions for children with autism. American Journal of Intellectual and Developmental Disabilities, 114(1), 23–41.Google Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.PubMedCrossRefGoogle Scholar
- Wechsler, D. (2003). Wechsler intelligence scale for children (4th ed.). San Antonio, TX: The Psychological Corporation.Google Scholar