Journal of Autism and Developmental Disorders

, Volume 41, Issue 1, pp 130–130 | Cite as

Can Retaining Asperger Syndrome in DSM V Help Establish Neurobiological Endophenotypes?

  • Ahmad Ghanizadeh
Letter to the Editor


School Psychology Genetic Risk Etiological Factor Neural Mechanism Asperger Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

I studied with interest the article entitled as: “Brief Report: Should the DSM V Drop Asperger Syndrome?” (Ghaziuddin 2010). The core symptoms and possible proposed changes for improving Asperger syndrome definition were discussed and he recommended that Asperger syndrome be retained in the DSM V.

Endophenotypes may help us to find association of behavioral manifestations and basic neurosciences etiology of diagnoses. Autism endophenotypes have also been suggested (Rommelse et al. 2009; Saresella et al. 2009). Endophenotypes of language impairment may offer promising approaches for further genetic and neurobiological studies (Geschwind 2009). This may be particularly relevant for the study of neural mechanisms that mediate genetic risk and clinical features.

Interest in possible PDD subtypes has increased in recent years. Our knowledge of connections to underlying genetic and neural mechanisms remains limited. For example, the issue of co-morbid ADHD and Autism diagnosis is of interest (Sinzig et al. 2009) particularly given the recent report of shared heritability for ADHD and PDDs (Rommelse et al.). Deliniation of possible endophenotypes may help us to know if it is possible that there is a common etiological factor.


  1. Geschwind, D. H. (2009). Advances in autism. Annual Review of Medicine, 60, 367–380.CrossRefPubMedGoogle Scholar
  2. Ghaziuddin, M. (2010). Brief report: Should the DSM V drop asperger syndrome? Journal of Autism and Developmental Disorders. [Epub ahead of print].Google Scholar
  3. Rommelse, N. N., Altink, M. E., Fliers, E. A., Martin, N. C., Buschgens, C. J., Hartman, C. A., et al. (2009). Comorbid problems in ADHD: Degree of association, shared endophenotypes, and formation of distinct subtypes. Implications for a future DSM. Journal of Abnormal Child Psychology, 37(6), 793–804.CrossRefPubMedGoogle Scholar
  4. Rommelse, N. N., Franke, B., Geurts, H. M., Hartman, C. A., & Buitelaar, J. K. (2010). Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder. European Child & Adolescent Psychiatry, 19(3), 281–295.Google Scholar
  5. Saresella, M., Marventano, I., Guerini, F. R., Mancuso, R., Ceresa, L., Zanzottera, M., et al. (2009). An autistic endophenotype results in complex immune dysfunction in healthy siblings of autistic children. Biological Psychiatry, 66(10), 978–984.CrossRefPubMedGoogle Scholar
  6. Sinzig, J., Walter, D., & Doepfner, M. (2009). Attention deficit/hyperactivity disorder in children and adolescents with autism spectrum disorder: Symptom or syndrome? Journal of Attention Disorders, 13(2), 117–126.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Shiraz University of Medical SciencesResearch Center for Psychiatry and Behavioral SciencesShirazIran

Personalised recommendations