Food-related Neural Circuitry in Prader-Willi Syndrome: Response to High- Versus Low-calorie Foods
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Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by hyperphagia and food preoccupations. Although dysfunction of the hypothalamus likely has a critical role in hyperphagia, it is only one of several regions involved in the regulation of eating. The purpose of this research was to examine food-related neural circuitry using functional magnetic resonance imaging in individuals with PWS and matched controls. Individuals with PWS showed increased activation in neural circuitry known to mediate hunger and motivation (hypothalamus, OFC) in response to high- versus low-calorie foods and in comparison to controls. This suggests neural circuitry for PWS is abnormally activated during hunger, particularly for high-calorie foods, and may mediate abnormally strong hunger states, therefore playing a significant role in PWS-induced hyperphagia.
KeywordsPrader-Willi syndrome fMRI Hypothalamus Food-related Genetic
This work was supported by grant PO1 HD 03008 from the National Institute of Child Health and Human Development and T32 MH 18268 from the National Institute of Mental Health. We thank the individuals and their families for their participation in this study. We would also like to thank Carley Piatt, Elinora Hunyadi, Jennifer Hetzke, Cheryl Klaiman, and the technicians of the Yale MR Imaging Center for their assistance with this research.
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