Brief Report: Identical Male Twins Concordant for Asperger’s Disorder
- 143 Downloads
The first case study of identical male twins concordant for DSM-IV Asperger’s disorder (ASD) was presented. Their monozygocity was confirmed by short tandem repeat analyses with a probability of 99.999963%. Despite sharing the same DNA and environment, the twins are different in comorbidity (i.e., major depressive disorder in the elder and absence seizure in the younger) and in IQs and motor performance (i.e., the elder was lower in IQs and clumsier). Both of them were normal in computed tomographic scanning and magnetic resonance imaging discordant with some previous reports of brain imaging abnormalities in ASD. Further studies are needed to clarify inherited/acquired epigenetic defects and brain imaging abnormalities relating to behavioral phenotypes in ASD twins.
KeywordsAsperger’s disorder Comorbidity Genetics Monozygotic twins Pervasive developmental disorders
We wish to thank for the twins and their mother for permission to publish this paper.
- American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.Google Scholar
- Ritvo, E. R., Freeman, B. J., Mason-Brothers, A., Mo, A., & Ritvo, A. M. (1985). Concordance for the syndrome of autism in 40 pairs of afflicted twins. American Journal of Psychiatry, 42, 74–77.Google Scholar
- World Health Organization. (1993). The ICD-10 classification of mental and behavioral disorders: diagnostic criteria for research. Geneva: World Health Organization.Google Scholar