Abstract
The first case study of identical male twins concordant for DSM-IV Asperger’s disorder (ASD) was presented. Their monozygocity was confirmed by short tandem repeat analyses with a probability of 99.999963%. Despite sharing the same DNA and environment, the twins are different in comorbidity (i.e., major depressive disorder in the elder and absence seizure in the younger) and in IQs and motor performance (i.e., the elder was lower in IQs and clumsier). Both of them were normal in computed tomographic scanning and magnetic resonance imaging discordant with some previous reports of brain imaging abnormalities in ASD. Further studies are needed to clarify inherited/acquired epigenetic defects and brain imaging abnormalities relating to behavioral phenotypes in ASD twins.
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References
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.
Amir, R. E., Van der Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., Zoghbi, H. Y. (1999). Rett syndrome is caused by mutations in X-linked MeCP2, encoding methyl-CpG-binding protein 2. Nature Genetics, 23, 185–188.
Asperger, H. (1944). Die “autistichen Psychopathen” im Kindersalter. Archive für Psychiatrie und Nervenkrankheiten, 117, 76–136.
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., et al. (1995). Autism as a strongly genetic disorder: evidence from a British twin study. Psychological Medicine,25, 63–77.
Berthier, M. L., Kulisevsky, J., Asenjo, B., Aparicio, J., & Lara, D. (2003). Comorbid Asperger and Tourette syndromes with localized mesencephalic, infrathalamic, thalamic, and striatal damage. Developmental Medicine and Child Neurology, 45, 207–212.
Burgoine, E., & Wing, L. (1983). Identical triplets with Asperger’s syndrome. British Journal of Psychiatry, 143, 261–265.
Dennis, C. (2003). Epigenetics and disease: altered states. Nature, 421, 686–688.
Folstein, S., & Rutter, M. (1977a). Genetic influences and infantile autism. Nature, 265, 726–728.
Folstein, S., & Rutter, M. (1977b). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, 18, 291–321.
Ghaziuddin, M., Weidmer-Mikhail, E., & Ghaziuddin, N. (1998). Comorbidity of Asperger syndrome: preliminary report. Journal of Intellectual Disability Research, 42, 279–283.
Goldstein, G., Beers, S. R., Siegel, D. J., & Minshew, N. J. (2001). A comparison of WAIS-R-profiles in adults with high-functioning autism or differing subtypes of learning disability. Applied Neuropsychology, 8, 148–154.
Ritvo, E. R., Freeman, B. J., Mason-Brothers, A., Mo, A., & Ritvo, A. M. (1985). Concordance for the syndrome of autism in 40 pairs of afflicted twins. American Journal of Psychiatry, 42, 74–77.
Steffenburg, S., Gillberg, C., Hellgren, L., Andersson, L., Gillberg, I. C., Jakobsson, G., et al. (1989). A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden. Journal of Child Psychology and Psychiatry, 30, 405–416.
Wing, L. (1981). Asperger’s syndrome: a clinical account. Psychological Medicine, 11, 115–129.
World Health Organization. (1993). The ICD-10 classification of mental and behavioral disorders: diagnostic criteria for research. Geneva: World Health Organization.
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We wish to thank for the twins and their mother for permission to publish this paper.
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Ishijima, M., Kurita, H. Brief Report: Identical Male Twins Concordant for Asperger’s Disorder. J Autism Dev Disord 37, 386–389 (2007). https://doi.org/10.1007/s10803-006-0150-x
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DOI: https://doi.org/10.1007/s10803-006-0150-x