Journal of Autism and Developmental Disorders

, Volume 37, Issue 2, pp 386–389 | Cite as

Brief Report: Identical Male Twins Concordant for Asperger’s Disorder

  • Michiko Ishijima
  • Hiroshi Kurita
Original paper


The first case study of identical male twins concordant for DSM-IV Asperger’s disorder (ASD) was presented. Their monozygocity was confirmed by short tandem repeat analyses with a probability of 99.999963%. Despite sharing the same DNA and environment, the twins are different in comorbidity (i.e., major depressive disorder in the elder and absence seizure in the younger) and in IQs and motor performance (i.e., the elder was lower in IQs and clumsier). Both of them were normal in computed tomographic scanning and magnetic resonance imaging discordant with some previous reports of brain imaging abnormalities in ASD. Further studies are needed to clarify inherited/acquired epigenetic defects and brain imaging abnormalities relating to behavioral phenotypes in ASD twins.


Asperger’s disorder Comorbidity Genetics Monozygotic twins Pervasive developmental disorders 



We wish to thank for the twins and their mother for permission to publish this paper.


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  1. 1.Department of NeuropsychiatryUniversity of Tokyo Medical CenterBunkyo-ku, TokyoJapan
  2. 2.Zenkoku Ryoiku-Sodan CenterTokyoJapan

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