Novel Measures of Response Performance and Inhibition in Children with ADHD

  • Sharon Morein-Zamir
  • Paul Hommersen
  • Charlotte Johnston
  • Alan Kingstone


Fifteen children with ADHD aged 8 to 12 years and age and gender matched controls performed two different stopping tasks to examine response performance and inhibition and their respective moment-to-moment variability. One task was the well-established stop-signal task, while the other was a novel tracking task where the children tracked a spaceship on the screen until an alarm indicated they should stop. Although performance was discrete in the stop signal task and continuous in the tracking task, in both tasks latencies to the stop signal were significantly slowed in children with ADHD. Go performance and variability did not significantly differ between ADHD and control children in either task. Importantly, stopping latency in the novel spaceship tracking task also was more variable in children with ADHD. As stopping variability cannot be measured using the standard stop signal task, the new task offers compelling support for the heretofore untested prediction that stopping is both slowed and more variable in children with ADHD. The results support a response inhibition impairment in ADHD, whilst limiting the extent of an intra-trial variability deficit.


ADHD Inhibition Stop signal Response control Response variability 



This research was supported by a University of British Columbia PhD fellowship to SM, and grants to C.J. by the Canadian Institutes of Health Research and Social Sciences and Humanities Research Council of Canada and to A.K. from the Natural Science and Engineering Research Council of Canada and the Social Sciences and Humanities Research Council of Canada. The authors would also like to thank Mandy Chen and Paul Nagelkerke for their assistance during data collection and processing.


  1. American Psychiatric Association (2000). Diagnostic and statistical manual—IV (text revision). Washington, DC.Google Scholar
  2. Band, G. P. H., van der Molen, M. W., & Logan, G. D. (2003). Horse-race model simulations of the stop-signal procedure. Acta Psychologica, 112, 105–142.PubMedCrossRefGoogle Scholar
  3. Barkley, R. A. (1997). Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychological Bulletin, 121, 65–94.PubMedCrossRefGoogle Scholar
  4. Barkley, R. A. (2006). Attention-deficit/hyperactivity disorder: A handbook for diagnosis and treatment (2nd ed.). New York: Guilford.Google Scholar
  5. Bekker, E. M., Kenemans, J. L., Hoeksma, M. R., Talsma, D., & Verbaten, M. N. (2005). The pure electrophysiology of stopping. International Journal of Psychophysiology, 55, 191–198.PubMedCrossRefGoogle Scholar
  6. Cabel, D. W. J., Armstong, I. T., Reingold, E., & Munoz, D. P. (2000). Control of saccade initiation in a countermanding task using visual and auditory stop signals. Experimental Brain Research, 133, 431–441.CrossRefGoogle Scholar
  7. Casada, J. H., & Roache, J. D. (2005). Behavioral inhibition and activation in posttraumatic stress disorder. The Journal of Nervous and Mental Disease, 193, 102–109.PubMedCrossRefGoogle Scholar
  8. Castellanos, F. X., Sonuga-Barke, E. J., Milham, M. P., & Tannock, R. (2006). Characterizing cognition in ADHD: beyond executive dysfunction. Trends in Cognitive Science, 10, 117–123.CrossRefGoogle Scholar
  9. Castellanos, F. X., Sonuga-Barke, E. J., Scheres, A., Di Martino, A., Hyde, C., & Walters, J. R. (2005). Varieties of attention-deficit/hyperactivity disorder-related intra-individual variability. Biological Psychiatry, 57, 1416–1423.PubMedCrossRefGoogle Scholar
  10. Castellanos, F. X., & Tannock, R. (2002). Neuroscience of attention-deficit hyperactivity disorder: the search for endophenotypes. Nature Reviews Neuroscience, 3, 617–628.PubMedGoogle Scholar
  11. Chevrier, A. D., Noseworthy, M. D., & Schachar, R. (2007). Dissociation of response inhibition and performance monitoring in the stop signal task using event-related fMRI. Human Brain Mapping, 28, 1347–1358.PubMedCrossRefGoogle Scholar
  12. Colonius, H., Ozyrt, J., & Arndt, P. A. (2001). Countermanding saccades with auditory stop signals: testing the race model. Vision Research, 41, 1951–1968.PubMedCrossRefGoogle Scholar
  13. DuPaul, G. J., Power, T. J., Anastopoulos, A. D., & Reid, R. (1998). ADHD Rating Scale—IV: Checklists, norms, and clinical interpretation. New York: Guilford.Google Scholar
  14. Eriksen, B. A., & Eriksen, C. W. (1974). Effects of noise letters upon the identification of a target letter in a nonsearch task. Perception & Psychophysics, 16(1), 143–149.Google Scholar
  15. Hommel, B., Musseler, J., Aschersleben, G., & Prinz, W. (2002). The Theory of Event Coding (TEC): A framework for perception and action planning. Behavioural Brain Science, 24, 849–878.Google Scholar
  16. Hommersen, P., Murray, C., Ohan, J. L., & Johnston, C. (2006). The Oppositional Defiant Disorder Rating Scale: Preliminary evidence of reliability and validity. Journal of Emotional and Behavioral Disorders, 14, 118–125.CrossRefGoogle Scholar
  17. Lappin, J. S., & Eriksen, C. W. (1966). Use of a delayed signal to stop a visual reaction-time response. Journal of Experimental Psychology, 72(6), 805–811.CrossRefGoogle Scholar
  18. Lawrence, V., Houghton, S., Tannock, R., Douglas, G., Durkin, K., & Whiting, K. (2002). ADHD outside the laboratory: Boy’s executive function performance on tasks in videogame play and on a visit to the zoo. Journal of Abnormal Child Psychology, 30, 447–462.PubMedCrossRefGoogle Scholar
  19. Leth-Steensen, C., Elbaz, Z. K., & Douglas, V. I. (2000). Mean response times, variability, and skew in the responding of ADHD children: A response time distributional approach. Acta Psychologica, 104, 167–190.PubMedCrossRefGoogle Scholar
  20. Lijffijt, M., Kenemans, J. L., Verbaten, M. N., & van Engeland, H. (2005). A meta-analytic review of stopping performance in attention-deficit/hyperactivity disorder: Deficient inhibitory motor control? Journal of Abnormal Psychology, 114, 216–222.PubMedCrossRefGoogle Scholar
  21. Logan, G. D. (1994). On the ability to inhibit thought and action: A users’ guide to the stop signal paradigm. In D. Dagenbach, & T. H. Carr (Eds.), Inhibitory processes in attention, memory, and language (pp. 214–249). San Diego: Academic.Google Scholar
  22. Logan, G. D., & Cowan, W. B. (1984). On the ability to inhibit thought and action: A theory of an act of control. Psychological Review, 91, 295–327.CrossRefGoogle Scholar
  23. McGarry, T., & Franks, I. M. (1997). A horse race between independent processes: Evidence for a phantom point of no return in the preparation of a speeded motor response. Journal of Experimental Psychology: Human Perception and Performance, 23, 1533–1542.PubMedCrossRefGoogle Scholar
  24. Michel, J. A., Kerns, K. A., & Mateer, C. A. (2005). The effect of reinforcement variables on inhibition in children with ADHD. Child Neuropsychology, 11, 295–302.PubMedCrossRefGoogle Scholar
  25. Morein-Zamir, S., Chua, R., Franks, I., Nagelkerke, P., & Kingstone, A. (2007). Predictability influences stopping and response control. Journal of Experimental Psychology: Human Perception and Performance, 33, 149–162.PubMedCrossRefGoogle Scholar
  26. Morein-Zamir, S., & Meiran, N. (2003). Individual stopping times and cognitive control: converging evidence for the stop signal task from a continuous tracking paradigm. Quarterly Journal of Experimental Psychology. A, 56, 469–489.Google Scholar
  27. Morein-Zamir, S., Nagelkerke, P., Chua, R., Franks, I., & Kingstone, A. (2004). Inhibiting prepared and ongoing responses: Is there more than one kind of stopping? Psychonomic Bulletin & Review, 11, 1034–1040.Google Scholar
  28. Morein-Zamir, S., Nagelkerke, P., Chua, R., Franks, I., & Kingstone, A. (2006a). Compatibility effects in stopping and response initiation in a continuous tracking task. Quarterly Journal of Experimental Psychology, 59(12), 2148–2161.CrossRefGoogle Scholar
  29. Morein-Zamir, S., Nagelkerke, P., Chua, R., Franks, I., & Kingstone, A. (2006b). Measuring online volitional response control with a continuous tracking task. Behavioral Research Methods, 38, 638–647.Google Scholar
  30. Nigg, J. T. (2001). Is ADHD a disinhibitory disorder? Psychological Bulletin, 127, 571–598.PubMedCrossRefGoogle Scholar
  31. Oosterlaan, J., Logan, G. D., & Sergeant, J. A. (1998). Response inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious and control children: A meta-analysis of studies with the stop task. Journal of Child Psychology and Psychiatry, 39, 411–425.PubMedCrossRefGoogle Scholar
  32. Pelman Jr., W. E., Fabiano, G. A., & Massetti, G. M. (2005). Evidenced based assessment of attention deficit hyperactivity disorder in children and adolescents. Journal of Clinical Child and Adolescent Psychology, 34, 449–476.CrossRefGoogle Scholar
  33. Quay, H. C. (1997). Inhibition and attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 25, 7–13.PubMedCrossRefGoogle Scholar
  34. Rieger, M., & Gauggel, S. (1999). Inhibitory after-effects in the stop signal paradigm. British Journal of Psychology, 90, 509–518.CrossRefGoogle Scholar
  35. Rubia, K., Russell, T., Overmeyer, S., Brammer, M. J., Bullmore, E. T., Sharma, T., et al. (2001). Mapping motor inhibition: Conjunctive brain activations across different versions of go/no-go and stop tasks. NeuroImage, 13, 250–261.PubMedCrossRefGoogle Scholar
  36. Schachar, R. J., Chen, S., Logan, G. D., Ornstein, T. J., Crosbie, J., Ickowicz, A., et al. (2004). Evidence for an error monitoring deficit in attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 32, 285–293.PubMedCrossRefGoogle Scholar
  37. Schachar, R., & Logan, G. D. (1990). Impulsivity and inhibitory control in normal development and childhood psychopathology. Developmental Psychology, 26, 710–720.CrossRefGoogle Scholar
  38. Schachar, R., Logan, G. D., Robaey, P., Chen, S., Ickowicz, A., & Barr, C. (2007). Restraint and cancellation: multiple inhibition deficits in attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 35, 229–238.PubMedCrossRefGoogle Scholar
  39. Scheres, A., Oosterlaan, J., & Sergeant, J. A. (2001). Response execution and inhibition in children with AD/HD and other disruptive disorders: the role of behavioural activation. Journal of Child Psychology & Psychiatry, 42, 347–357.CrossRefGoogle Scholar
  40. Scheres, A., Oosterlaan, J., Swanson, J., Morein-Zamir, S., Meiran, N., Schut, H., et al. (2003). The effect of methylphenidate on three forms of response inhibition in boys with AD/HD. Journal of Abnormal Child Psychology, 31, 107–122.CrossRefGoogle Scholar
  41. Sergeant, J. A. (2005). Modelling attention-deficit/hyperactivity disorder: A critical appraisal of the cognitive-energetic model. Biological Psychiatry, 57, 1248–1255.PubMedCrossRefGoogle Scholar
  42. Sergeant, J. A., Oosterlaan, J., & Van der Meere, J. (1999). Information processing in attention-deficit/hyperactivity disorder. In H. C. Quay, & A. E. Hogan (Eds.), Handbook of disruptive behaviour disorders (pp. 75–104). New York: Plenum.Google Scholar
  43. Slusarek, M., Velling, S., Bunk, D., & Eggers, C. (2001). Motivational effects on inhibitory control in children with ADHD. Journal of American Academy Child Adolescent Psychiatry, 40(3), 355–363.CrossRefGoogle Scholar
  44. Solanto, M. V., Abikoff, H., Sonuga-Barke, E., Schachar, R., Logan, G. D., Wigal, T., et al. (2001). The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD: A supplement to the NIMH multimodal treatment study of AD/HD. Journal of Abnormal Child Psychology, 29(3), 215–228.PubMedCrossRefGoogle Scholar
  45. Tannock, R. (2003). Neuropsychology of attention disorders. In S. J. Segalowitz, & I. Rapin (Eds.),Volume 8 of handbook of neuropsychology (pp. 753–784, 2nd ed.). Amsterdam: Elsevier.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Sharon Morein-Zamir
    • 1
    • 2
  • Paul Hommersen
    • 1
  • Charlotte Johnston
    • 1
  • Alan Kingstone
    • 1
  1. 1.Psychology DepartmentUniversity of British ColumbiaVancouverCanada
  2. 2.Department of PsychiatryUniversity of CambridgeCambridgeUK

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