Clinical features of uveitis in elderly patients in central Tokyo (2013–2018)



To clarify the clinical features of uveitis in elderly patients in central Tokyo.


We retrospectively identified 1424 patients with uveitis who visited the Uveitis Clinic of the University of Tokyo Hospital between January 2013 and December 2018. The patients were categorized into two groups based on their ages at the time of disease onset: patients aged 65 years or older were included in Group A, whereas those younger than 65 years were included in Group B. The etiological classification of uveitis and its causes were investigated for each group.


Group A presented significantly higher rates of infectious uveitis (35.5% vs. 17.8%, p < 0.0001) and masquerade syndromes (17.9% vs. 5.0%, p < 0.0001) than Group B. Furthermore, Group A had significantly higher rates of sarcoidosis (23.1% vs. 9.3%, p < 0.0001), intraocular lymphoma (16.6% vs. 4.6%, p < 0.0001), cytomegalovirus iritis (11.0% vs. 5.6%, p = 0.0043), and cytomegalovirus retinitis (5.2% vs. 1.5%, p = 0.0020) than Group B.


Our results demonstrate a clear difference in the causative diseases of uveitis between elderly and non-elderly patients. These findings may support ophthalmologists in their diagnostic process for elderly patients with uveitis.

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Code availability

Not applicable.

Data availability

The datasets used and analyzed during the current study can be obtained from the corresponding author on reasonable request.


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We would like to thank Editage for English language editing.


This study was supported by a grant from the Japan Foundation for Applied Enzymology (2019).

Author information




S.S., H.S., R.T., and T.K. designed the research strategies, collected the data, and wrote the manuscript. H.F., H.I., K.K., and H.N. collected the data and wrote the manuscript. H.K. and M.A wrote and revised the manuscript.

Corresponding author

Correspondence to Shintaro Shirahama.

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Opt-out consent was obtained from all patients. This is a method used for the recruitment of participants into studies where information is provided to the potential participant regarding the research and their involvement and where their participation is presumed unless they decline to participate.

Ethics approval

This retrospective study was approved by the Research Ethics Committee of the Graduate School of Medicine and the Faculty of Medicine at the University of Tokyo. It was conducted in accordance with the tenets of the Declaration of Helsinki.

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Shintaro Shirahama and Hirotsugu Soga were co–first authors.

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Shirahama, S., Soga, H., Tanaka, R. et al. Clinical features of uveitis in elderly patients in central Tokyo (2013–2018). Int Ophthalmol (2021).

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  • Infectious uveitis
  • Sarcoidosis
  • Intraocular lymphoma
  • Tokyo
  • Elderly patients