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Quantitative analysis of retinal microcirculation in optical coherence tomography angiography in cases with Behçet’s disease without ocular involvement

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Abstract

Purpose

To evaluate the retinal vascular plexus and choriocapillaris structures in patients with non-ocular Behçet’s disease (BD) using optical coherence tomography angiography (OCTA).

Methods

The study included 42 eyes of non-ocular BD patients (study group) and 40 eyes of 20 healthy subjects (control group). Flow area (mm2), mean vascular density (VD) (%) and foveal avascular zone (FAZ) (mm2) were measured using OCTA (Optovue Inc., Fremont, CA, USA). Subfoveal choroidal thickness (CT) (μm) and central macular thickness (CMT) (μm) measurements were also performed.

Results

The mean superficial capillary plexus, deep capillary plexus and choriocapillaris flow area values were found to be significantly lower in the study group than in the control group (p < 0.001, p < 0.001, p = 0.008, respectively). In respect of mean VD, a statistically significant difference was determined between the study and control groups in both superficial and deep VD (p < 0.001). No statistically significant difference was found out between the groups in respect of superficial FAZ, deep FAZ and CMT (p = 0.165, p = 0.477, p = 0.457, respectively). The subfoveal CT was also measured to be significantly thicker in the study group than in the control group (p < 0.001).

Conclusion

The results obtained with OCTA revealed that there could be both retinal and choroidal involvement in non-ocular BD patients before the emergence of evident clinical findings.

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Authors and Affiliations

  1. Department of Opthalmology, Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey

    Ayşegül Çömez & Abdullah Beyoğlu

  2. Department of Opthalmology, Selcuk University Faculty of Medicine, Konya, Turkey

    Yalçın Karaküçük

Authors
  1. Ayşegül Çömez
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  2. Abdullah Beyoğlu
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  3. Yalçın Karaküçük
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Correspondence to Ayşegül Çömez.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained from each participant included in the study.

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Çömez, A., Beyoğlu, A. & Karaküçük, Y. Quantitative analysis of retinal microcirculation in optical coherence tomography angiography in cases with Behçet’s disease without ocular involvement. Int Ophthalmol 39, 2213–2221 (2019). https://doi.org/10.1007/s10792-018-1059-z

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  • DOI: https://doi.org/10.1007/s10792-018-1059-z

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