Dear Editor,

We thank colleagues Tsatsos et al. [1, 2] for sharing their experience on this controversial topic. Indeed, on the one hand, performing keratoplasty while leaving a stable anterior chamber intraocular lens (acIOL) in situ may be considered as the least invasive choice. On the other hand, exchanging an acIOL for a retroiridal one prior to keratoplasty restores the anterior segment anatomy to a better degree and may offer a longer graft survival.

The combination of endothelial keratoplasty with IOL exchange and fixation of the secondary IOL by gluing through scleral flaps as proposed by Narang et al. [2, 3] is a promising new technique that has been performed on a small number of cases up to date. Thus, regardless of the fixation technique (i.e., sutured or glued), studies reporting long-term graft survival are needed to confirm the superiority of sclera-fixated IOLs versus acIOLs.

We also agree with the comment of Tsatsos et al. regarding graft thickness in eyes with acIOL undergoing DSAEK. Indeed, as mentioned in “Results” section, we used thin or ultrathin DSAEK grafts with a diameter below 100 μm [1].

Finally, also in our case series, a well-positioned acIOL and a deep anterior chamber were prerequisites for leaving an acIOL in situ as suggested by Esquenazi et al. [4].