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Elevated lipocalin-2 level in aqueous humor of patients with central retinal vein occlusion

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Abstract

Purpose

To assess the concentrations of lipocalin-2 (LCN2) in the serum and the aqueous humor of patients with central retinal vein occlusion (CRVO).

Methods

The concentrations of LCN2 in the serum and aqueous humor of 16 cataract patients and 16 patients with CRVO with macular edema were compared. Collection of aqueous samples was conducted in the operating theater under sterile conditions and just prior to intravitreal ranibizumab injection or cataract surgery. LCN2 levels in serum and aqueous humor samples were measured using a commercial kit (human lipocalin-2/NGAL PicoKine ELISA Kit, MyBioSource Inc., USA; Catalog No: MBS175829) based on standard sandwich enzyme-linked immunosorbent assay technology.

Results

The concentrations of LCN2 in the aqueous humors of the CRVO group were higher than those of the control group (p = 0.021). There was no significant difference in serum LCN2 level between the two groups (p = 0.463).

Conclusions

Concentrations of LCN2 in aqueous humor are increased in CRVO. LCN2 may be part of a pro-catabolic phenotype, and it may play an important role in the dreaded complications of CRVO, such as macular edema, macular ischemia, and neovascularization, which lead to blindness.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, Kafkas University, Kars, Turkey

    Yaran Koban

  2. Department of Biochemistry, Faculty of Medicine, Kafkas University, Kars, Turkey

    Seda Sahin, Fatih Boy & Fatih Kara

Authors
  1. Yaran Koban
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  2. Seda Sahin
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  3. Fatih Boy
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  4. Fatih Kara
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Correspondence to Yaran Koban.

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Authors do not have any financial interest in any products mentioned in this article.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Koban, Y., Sahin, S., Boy, F. et al. Elevated lipocalin-2 level in aqueous humor of patients with central retinal vein occlusion. Int Ophthalmol 39, 981–986 (2019). https://doi.org/10.1007/s10792-018-0894-2

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  • DOI: https://doi.org/10.1007/s10792-018-0894-2

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