International Ophthalmology

, Volume 39, Issue 4, pp 777–781 | Cite as

Longitudinal quantitative assessment of macula during therapy with fingolimod in relapsing–remitting multiple sclerosis

  • Mario FruschelliEmail author
  • Marco Capozzoli
  • Maria Chiara Gelmi
  • Gianni Masi
  • Pasquale Annunziata
Original Paper



Fingolimod is the first oral drug approved for treatment of relapsing–remitting multiple sclerosis (RR-MS), and it has potential macular side effects. Despite the qualitative evidence of macular oedema under treatment, longitudinal quantitative assessment is lacking. To address this issue, we measured macular volume and central foveal thickness in a cohort of MS patients on fingolimod over 12 months of treatment.


Central foveal thickness (CFT) and total macular volume (TMV) were longitudinally recorded with spectral-domain optical coherence tomography in a cohort of 23 RR-MS patients treated with fingolimod at baseline, 3, 6 and 12 months. OCT parameters were analysed considering previous history of optic neuritis (ON). Comparison of means was performed with variance analysis (ANOVA).


Macular oedema occurred in none of the patients. Comparing both groups of patients (with and without previous ON), no statistically significant difference was found during the follow-up both for CFT and TMV (p = 0.99 and p = 0.96, respectively) although a slight early but not significant TMV reduction was detected.


In our cohort, therapy with fingolimod did not cause any change in CFT and TMV in MS patients during a 12-month follow-up independent of previous ON.


Multiple sclerosis Optic neuritis Fingolimod Spectral-domain optical coherence tomography Central foveal thickness Total macular volume 


Compliance with ethical standards

Conflict of interest

This is an independent work not supported by any sponsor. The authors have no financial interest regarding the content of this paper.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Ophthalmology Unit, Department of Medicine, Surgery and NeurosciencesUniversity of SienaSienaItaly
  2. 2.Graduate School of Ophthalmology, Department of Medicine, Surgery and NeurosciencesUniversity of SienaSienaItaly
  3. 3.Clinical Neuroimmunology Unit, Department of Medicine, Surgery and NeurosciencesUniversity of SienaSienaItaly
  4. 4.Dipartimento di Scienze Mediche, Chirurgiche e NeuroscienzeUniversità di SienaSienaItaly

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