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Dry eye evaluation and correlation analysis between tear film stability and corneal surface regularity after small incision lenticule extraction

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Abstract

Purpose

To investigate the dry eye after small incision lenticule extraction (SMILE) and explore the correlations between changes in the tear film stability, the tear secretion and the corneal surface regularity.

Methods

Sixty-two eyes of 22 men and 13 women who underwent SMILE were included in this study. Corneal topography was measured to assess the index of surface variance (ISV) and the index of vertical asymmetry (IVA). Dry eye tests including subjective symptom questionnaire, tear breakup time (TBUT), corneal fluorescein staining and Schirmer’s test (ST) were evaluated before and at 1 and 6 months postoperatively.

Results

TBUT was found to be significantly decreased from 9.8 ± 3.4 s preoperatively to 7.4 ± 3.8 s at 1 month and 6.5 ± 3.6 s at 6 months (both P < 0.001). There was a significant decrease in ST at 1 month postoperatively (P = 0.012); however, ST returned to baseline by 6 months (P = 0.522). Both ISV and IVA significantly increased after the surgery (all P < 0.001). In addition, the changes in TBUT were negatively correlated with the increases in ISV and IVA (r = −0.343, P = 0.006 and r = −0.311, P = 0.014, respectively).

Conclusions

Patients undergoing SMILE might develop a short-TBUT type of dry eye. Corneal surface regularity indices might be helpful in the assessment of tear film stability following SMILE procedure.

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References

  1. Ang RT, Dartt DA, Tsubota K (2001) Dry eye after refractive surgery. Curr Opin Ophthalmol 12:318–322

    Article  CAS  Google Scholar 

  2. Albietz JM, Lenton LM, McLennan SG (2004) Chronic dry eye and regression after laser in situ keratomileusis for myopia. J Cataract Refract Surg 30:675–684

    Article  Google Scholar 

  3. Denoyer A, Rabut G, Baudouin C (2012) Tear film aberration dynamics and vision-related quality of life in patients with dry eye disease. Ophthalmology 119:1811–1818

    Article  Google Scholar 

  4. Goto E, Yagi Y, Matsumoto Y, Tsubota K (2002) Impaired functional visual acuity of dry eye patients. Am J Ophthalmol 133:181–186

    Article  Google Scholar 

  5. Shah R, Shah S, Sengupta S (2011) Results of small incision lenticule extraction: all-in-one femtosecond laser refractive surgery. J Cataract Refract Surg 37:127–137

    Article  Google Scholar 

  6. Demirok A, Ozgurhan EB, Agca A, Kara N, Bozkurt E, Cankaya KI, Yilmaz OF (2013) Corneal sensation after corneal refractive surgery with small incision lenticule extraction. Optom Vis Sci 90:1040–1047

    Article  Google Scholar 

  7. Qiu PJ, Yang YB (2016) Early changes to dry eye and ocular surface after small-incision lenticule extraction for myopia. Int J Ophthalmol 9:575–579

    PubMed  PubMed Central  Google Scholar 

  8. Li M, Zhao J, Shen Y, Li T, He L, Xu H, Yu Y, Zhou X (2013) Comparison of dry eye and corneal sensitivity between small incision lenticule extraction and femtosecond LASIK for myopia. PLoS ONE 8:e77797

    Article  CAS  Google Scholar 

  9. Zhang C, Ding H, He M, Liu L, Liu L, Li G, Niu B, Zhong X (2016) Comparison of early changes in ocular surface and inflammatory mediators between femtosecond lenticule extraction and small-incision lenticule extraction. PLoS ONE 11:e0149503

    Article  Google Scholar 

  10. Liu Z, Pflugfelder SC (1999) Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency. Ophthalmology 106:939–943

    Article  CAS  Google Scholar 

  11. Kojima T, Ishida R, Dogru M, Goto E, Takano Y, Matsumoto Y, Kaido M, Ohashi Y, Tsubota K (2004) A new noninvasive tear stability analysis system for the assessment of dry eyes. Invest Ophthalmol Vis Sci 45:1369–1374

    Article  Google Scholar 

  12. Nettune GR, Pflugfelder SC (2010) Post-LASIK tear dysfunction and dysesthesia. Ocul Surf 8:135–145

    Article  Google Scholar 

  13. Wei S, Wang Y (2013) Comparison of corneal sensitivity between FS-LASIK and femtosecond lenticule extraction (ReLEx flex) or small-incision lenticule extraction (ReLEx smile) for myopic eyes. Graefes Arch Clin Exp Ophthalmol 251:1645–1654

    Article  Google Scholar 

  14. Vestergaard AH, Grauslund J, Ivarsen AR, Hjortdal JØ (2014) Efficacy, safety, predictability, contrast sensitivity, and aberrations after femtosecond laser lenticule extraction. J Cataract Refract Surg 40:403–411

    Article  Google Scholar 

  15. Denoyer A, Landman E, Trinh L, Faure JF, Auclin F, Baudouin C (2015) Dry eye disease after refractive surgery: comparative outcomes of small incision lenticule extraction versus LASIK. Ophthalmology 122:669–676

    Article  Google Scholar 

  16. Gao S, Li S, Liu L, Wang Y, Ding H, Li L, Zhong X (2014) Early changes in ocular surface and tear inflammatory mediators after small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis. PLoS ONE 9:e107370

    Article  Google Scholar 

  17. Xu Y, Yang Y (2014) Dry eye after small incision lenticule extraction and LASIK for myopia. J Refract Surg 30:186–190

    Article  CAS  Google Scholar 

  18. Battat L, Macri A, Dursun D, Pflugfelder SC (2001) Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology 108:1230–1235

    Article  CAS  Google Scholar 

  19. Bower KS, Sia RK, Ryan DS, Mines MJ, Dartt DA (2015) Chronic dry eye in photorefractive keratectomy and laser in situ keratomileusis: manifestations, incidence, and predictive factors. J Cataract Refract Surg 41:2624–2634

    Article  Google Scholar 

  20. Ozkan Y, Bozkurt B, Gedik S, Irkeç M, Orhan M (2001) Corneal topographical study of the effect of lacrimal punctum occlusion on corneal surface regularity in dry eye patients. Eur J Ophthalmol 11:116–119

    Article  CAS  Google Scholar 

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Acknowledgements

This study was supported by grants from the National Natural Science Foundation of China (Grant Nos. 81470658 and 81670884). The funding organization had no role in the design or conduct of this research.

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Authors and Affiliations

  1. Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, 300020, China

    Hui Zhang & Yan Wang

  2. Tianjin Eye Hospital, No 4. Gansu Road, Heping District, Tianjin, 300020, China

    Hui Zhang & Yan Wang

  3. Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, 300020, China

    Hui Zhang & Yan Wang

  4. Tianjin Eye Institute, Tianjin, 300020, China

    Hui Zhang & Yan Wang

Authors
  1. Hui Zhang
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  2. Yan Wang
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Correspondence to Yan Wang.

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Zhang, H., Wang, Y. Dry eye evaluation and correlation analysis between tear film stability and corneal surface regularity after small incision lenticule extraction. Int Ophthalmol 38, 2283–2288 (2018). https://doi.org/10.1007/s10792-017-0717-x

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  • DOI: https://doi.org/10.1007/s10792-017-0717-x

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