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Retrospective observation on trabeculectomy of primary congenital glaucoma by applying biological amniotic membranes soaked with 5-fluorouracil

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Abstract

Purpose

To report our experience on treatment of primary congenital glaucoma with trabeculectomy in combination with biological amniotic membranes soaked with 5-fluorouracil.

Methods

This is a retrospective study. Thirty primary congenital glaucoma (PCG) patients (41 eyes) were treated with trabeculectomy in combination with biological amniotic membranes soaked with 5-fluorouracil before operation and followed up for 2.75 ± 1.35 years in average ranging from 1.2 to 5.3 years (Group A). In addition, 22 PCG patients (32 eyes) treated with mitomycin C-trabeculectomy were selected as control and followed up for 2.3 ± 1.25 years in average ranging from 1.4 to 5.1 years (Group B).

Results

Patients in Group A were 4.74 ± 2.13 years old. After treatment, their mean intraocular pressure decreased from preoperative 38.8 ± 11.3–17.6 ± 8.2 mmHg at 12 months of postoperation (P = 0.0000). At 12 months of follow-up, the intraocular pressure was less than 13 mmHg in 8 eyes (19.5%), between 17 and 13 mmHg in 15 eyes (36.6%), between 21 and 17 mmHg in 12 eyes (29.3%) and more than 21 mmHg in 6 eyes (14.6%). The overall success rate was 85.4%, and total complication rate was 17.1%. By comparison, the overall success rate and total complication rate were 87.5 and 34.4%, respectively, at 12 months of follow-up for patients in Group B. Although the overall success rate was not significantly different between Groups A and B (P = 0.1203) at the end of follow-up, the total complication rate was significantly decreased in Group A (P = 0.0419).

Conclusion

Application of trabeculectomy in combination with biological amniotic membranes soaked with 5-fluorouracil can be an effective surgical treatment method for primary congenital glaucoma patients.

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Acknowledgements

This study was supported by the Jinan City Health Science and Technology Development Plan (2008-13), the Jinan City Clinical Technology Development Plan (201503023) and the Shandong Provincial Science and Technology Department Key Research and Development Project (2015GSF118066).

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Authors and Affiliations

  1. Eye Reseach Institute, Jinan Eye Hospital, No. 148 Jingyi Road, Jinan, 250001, Shandong, People’s Republic of China

    Chenming Zhang & Wei Liu

  2. Infection Control Department, Jinan Eye Hospital, Jinan, 250001, Shandong, People’s Republic of China

    Jing Wang & Hui Gao

  3. Quality Control Office, Jinan Eye Hospital, Jinan, 250001, Shandong, People’s Republic of China

    Xiuqin Wang

  4. Nursing Department, Jinan Eye Hospital, Jinan, 250001, Shandong, People’s Republic of China

    Min Wu

  5. Ophthalmology Department, Jinan Eye Hospital, Jinan, 250001, Shandong, People’s Republic of China

    Bailing Guo & Chunlei Liu

Authors
  1. Chenming Zhang
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  8. Wei Liu
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Correspondence to Wei Liu.

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Zhang, C., Wang, J., Gao, H. et al. Retrospective observation on trabeculectomy of primary congenital glaucoma by applying biological amniotic membranes soaked with 5-fluorouracil. Int Ophthalmol 38, 1933–1940 (2018). https://doi.org/10.1007/s10792-017-0679-z

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  • DOI: https://doi.org/10.1007/s10792-017-0679-z

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