International Ophthalmology

, Volume 38, Issue 2, pp 793–798 | Cite as

A challenged case of Vogt–Koyanagi–Harada syndrome: when dermatological manifestations came first

  • Inês Coutinho
  • Catarina Pedrosa
  • Cristina Santos
  • Susana Pina
  • Maria Lisboa
  • Manuela Bernardo
  • Isabel Prieto
Case Report



Vogt–Koyanagi–Harada syndrome (VKHS) is an inflammatory systemic autoimmune disease principally affecting pigmented tissues in the ocular, auditory, integumentary and central nervous systems. Patients are generally women in the fourth decade of life. The prognosis is correlated mainly with the time between diagnosis and the start of treatment and number of recurrent episodes of inflammation. Most complications are mainly ocular. The purpose of this paper is to describe a clinical case of VKHS.

Material and methods

A child with a challenging clinical presentation in which the dermatological symptoms occurred before ocular manifestations.

Discussion and Conclusion

VKHS is rare in children and can be a diagnostic challenge. It seemed interesting to share this case as an opportunity to expand our knowledge of the clinical spectrum of diseases and reflect about current diagnostic criteria.


Vogt–Koyanagi–Harada syndrome Children Diagnosis Clinical presentation 


Compliance with ethical standards

Conflict of interest

There is no conflict of interest from any of the authors, and the manuscript has been read and approved by all the authors.


  1. 1.
    Rao NA, Gupta A, Dustin L, Chee SP, Okada AA, Khairallah M et al (2010) Frequency of distinguishing clinical features in Vogt–Koyanagi–Harada disease. Ophthalmology 117(3):591–599CrossRefPubMedGoogle Scholar
  2. 2.
    Nussenblatt RB, Whitcup SM (2010) Uveitis: fundamentals and clinical practice, 4th edn. Mosby Elsevier, Los AngelesGoogle Scholar
  3. 3.
    Read RW, Holland GN, Rao NA, Tabbara KF, Ohno S, Arellanes-Garcia L et al (2001) Revised diagnostic criteria for Vogt–Koyanagi–Harada disease: report of an international committee on nomenclature. Am J Ophthalmol 131(5):647–652CrossRefPubMedGoogle Scholar
  4. 4.
    Rathinam SR, Vijayalakshmi P, Namperumalsamy P, Nozik RA (1998) Vogt–Koyanagi–Harada syndrome in children. Ocul Immunol Inflamm 6(3):155–161CrossRefPubMedGoogle Scholar
  5. 5.
    Read RW, Rao NA (2000) Utility of existing Vogt–Koyanagi–Harada syndrome diagnostic criteria at initial evaluation of the individual patient: a retrospective analysis. Ocul Immunol Inflamm 8:227–234CrossRefPubMedGoogle Scholar
  6. 6.
    Berker N, Ozdamar Y, Soykan E, Ozdal P, Ozkan SS (2007) Vogt–Koyanagi–Harada syndrome in children: report of a case and review of the literature. Ocul Immunol Inflamm. 15(4):351–357CrossRefPubMedGoogle Scholar
  7. 7.
    Matiello M, Carvalho HC, Alvarenga H, Alvarenga RMP (2004) Síndrome de Vogt-Koyanagi-Harada. Cad Bras Med 17:50–58Google Scholar
  8. 8.
    Herbort CP, Mantovani A, Bouchenaki N (2007) Indocyanine green angiography in Vogt–Koyanagi–Harada disease: angiographic signs and utility in patient follow-up. Int Ophthalmol 27(2–3):173–182CrossRefPubMedGoogle Scholar
  9. 9.
    Bouchenaki N, Herbort CP (2011) Indocyanine green angiography guided management of Vogt–Koyanagi–Harada disease. J Ophthalmic Vis Res 6(4):241–248PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Inês Coutinho
    • 1
  • Catarina Pedrosa
    • 1
  • Cristina Santos
    • 1
  • Susana Pina
    • 2
  • Maria Lisboa
    • 1
  • Manuela Bernardo
    • 1
  • Isabel Prieto
    • 3
  1. 1.Hospital Prof Doutor Fernando FonsecaLisbonPortugal
  2. 2.Hospital Beatriz ÂngeloLisbonPortugal
  3. 3.Hospital Prof Doutor Fernando FonsecaLisbonPortugal

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