Cilioretinal artery occlusion and anterior ischemic optic neuropathy as the initial presentation in a child female carrier of Fabry disease
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To report the youngest female carrier of Fabry disease, complicated by cilioretinal artery occlusion and anterior ischemic optic neuropathy (AION).
An 11-year-old girl was referred to our clinic with painless, acute loss of vision in her right eye. Posterior segment examination and fluorescein angiography revealed cilioretinal artery occlusion and AION. Systemic evaluations were unremarkable, except for a low blood α-galactosidase A enzyme level of 242.27 pmol/spot*20 h (reference range: 450–2000 pmol/spot*20 h). The patient was diagnosed with female carrier of Fabry disease.
Retinal vascular occlusions are rare in childhood, and Fabry disease may present with retinal vascular occlusion. Ophthalmological examinations may be contributing for early detection of the disease. To the best of our knowledge, this is the first report of a child female carrier of Fabry disease, complicated by cilioretinal artery occlusion and AION.
KeywordsAnterior ischemic optic neuropathy Cilioretinal artery occlusion Fabry disease Female carrier
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Authors’ contribution statement
M. Giray Ersoz was involved in the diagnosis of patient, study organization, and writing. Gamze Türe was involved in the diagnosis of patient and writing.
Conflict of interest
The authors have no financial interests.