International Ophthalmology

, Volume 38, Issue 1, pp 233–239 | Cite as

The assessment of macular electrophysiology and macular morphology in patients with vitiligo

  • Rukiye Aydin
  • Mustafa Ozsutcu
  • Sevil Karaman Erdur
  • Funda Dikkaya
  • Ali Balevi
  • Merve Ozbek
  • Fevzi Senturk
Original Paper



We aimed to analyze the electrophysiologic function and morphology of macula in vitiligo patients.


Seventeen patients with vitiligo and 11 healthy subjects were studied. All participants underwent multifocal electroretinography (mfERG) and spectral domain optical coherence tomography (SD-OCT) evaluations. The mfERG (P1 mfERG responses central and peripheral) and retinal layer segmentation parameters (nine ETDRS subfields) were compared in vitiligo and control groups.


The mean P1 response amplitudes were significantly decreased in central and peripheral rings of the fovea in patients with vitiligo compared with controls (p = 0.002 and p = 0.006, respectively). There was a tendency toward a prolonged mean implicit time for both central and peripheral in patients with vitiligo compared to controls, however, with no statistical significance (p = 0.453 and p = 0.05, respectively). There was no statistically significant difference in all retinal layers thickness between two groups.


In patients with vitiligo, while photoreceptor segment preserved in SD-OCT, mfERG reduced showing potential decline in central retinal function. This study showed a potential decline in central retinal function in patients with vitiligo even if they have normal fundus appearance and SD-OCT findings.


Vitiligo Multifocal electroretinography Photoreceptor function Spectral domain optical coherence tomography 



No funding was received for this research.

Compliance with ethical standards

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.


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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Rukiye Aydin
    • 1
  • Mustafa Ozsutcu
    • 1
  • Sevil Karaman Erdur
    • 1
  • Funda Dikkaya
    • 1
  • Ali Balevi
    • 2
  • Merve Ozbek
    • 1
  • Fevzi Senturk
    • 1
  1. 1.Department of OphthalmologyIstanbul Medipol UniversityBagcılar, IstanbulTurkey
  2. 2.Department of DermatologyIstanbul Medipol UniversityIstanbulTurkey

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