International Ophthalmology

, Volume 38, Issue 1, pp 183–190 | Cite as

Peripapillary retinal nerve fiber layer and ganglion cell–inner plexiform layer thickness in adult-onset familial Mediterranean fever

  • Sait Alim
  • Mehmet Esen
  • Ayşe Kevser Demir
  • Selim Demir
  • Hüseyin Ortak
  • Alper Güneş
  • Tufan Alatli
  • Helin Deniz Demir
Original Paper



The purpose of the present study was to evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell–inner plexiform layer (GCIPL) in adult-onset familial Mediterranean fever (FMF).


Forty two adult-onset FMF patients and forty two healthy controls were included in the present study. Detailed ocular examination was performed, and then the thickness of the peripapillary RNFL and GCIPL was measured by Spectral domain optical coherence tomography. The patients were divided into two groups according to their disease severity score, M694V gene mutation, colchicine dosage used per day, colchicine usage time period and number of FMF attacks per year.


There were no statistically significant differences in peripapillary RNFL and retinal GCIPL thickness in patients with adult-onset FMF and controls.


According to our study, it looks like that neither adult-onset FMF nor colchicine has any effect on the RNFL and GCIPL thicknesses. Further studies with a large sample size are needed.


Colchicine Disease severity score M694V gene mutation Ganglion cell–inner plexiform layer thickness Retinal nerve fiber layer thickness Optical coherence tomography 



Authors are grateful to Mr. Osman DEMİR, Instructor (Gaziosmanpaşa University, School of Medicine, Department of Biostatistics) for his support in statistics of the present study.

Compliance with ethical standards

Conflict of interest

This study has no financial support, and the authors report no declarations of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standard.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  1. 1.Department of OphthalmologyGaziosmanpaşa University Faculty of MedicineTokatTurkey
  2. 2.Department of Emergency MedicineGaziosmanpaşa University Faculty of MedicineTokatTurkey
  3. 3.Department of Internal MedicineGaziosmanpaşa University Faculty of MedicineTokatTurkey

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