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Peripapillary retinal nerve fiber layer and ganglion cell–inner plexiform layer thickness in adult-onset familial Mediterranean fever

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Abstract

Objective

The purpose of the present study was to evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell–inner plexiform layer (GCIPL) in adult-onset familial Mediterranean fever (FMF).

Methods

Forty two adult-onset FMF patients and forty two healthy controls were included in the present study. Detailed ocular examination was performed, and then the thickness of the peripapillary RNFL and GCIPL was measured by Spectral domain optical coherence tomography. The patients were divided into two groups according to their disease severity score, M694V gene mutation, colchicine dosage used per day, colchicine usage time period and number of FMF attacks per year.

Results

There were no statistically significant differences in peripapillary RNFL and retinal GCIPL thickness in patients with adult-onset FMF and controls.

Conclusion

According to our study, it looks like that neither adult-onset FMF nor colchicine has any effect on the RNFL and GCIPL thicknesses. Further studies with a large sample size are needed.

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Acknowledgements

Authors are grateful to Mr. Osman DEMİR, Instructor (Gaziosmanpaşa University, School of Medicine, Department of Biostatistics) for his support in statistics of the present study.

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Authors and Affiliations

  1. Department of Ophthalmology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey

    Sait Alim, Selim Demir, Hüseyin Ortak, Alper Güneş & Helin Deniz Demir

  2. Department of Emergency Medicine, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey

    Mehmet Esen & Tufan Alatli

  3. Department of Internal Medicine, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey

    Ayşe Kevser Demir

Authors
  1. Sait Alim
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  2. Mehmet Esen
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  3. Ayşe Kevser Demir
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  4. Selim Demir
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  5. Hüseyin Ortak
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  6. Alper Güneş
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  7. Tufan Alatli
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  8. Helin Deniz Demir
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Correspondence to Sait Alim.

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Conflict of interest

This study has no financial support, and the authors report no declarations of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standard.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Alim, S., Esen, M., Demir, A.K. et al. Peripapillary retinal nerve fiber layer and ganglion cell–inner plexiform layer thickness in adult-onset familial Mediterranean fever. Int Ophthalmol 38, 183–190 (2018). https://doi.org/10.1007/s10792-017-0446-1

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  • DOI: https://doi.org/10.1007/s10792-017-0446-1

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