International Ophthalmology

, Volume 38, Issue 1, pp 175–181 | Cite as

A novel marker in acute central serous chorioretinopathy: thiol/disulfide homeostasis

  • Hasan Altinkaynak
  • Piraye Zeynep Kurkcuoglu
  • Mehtap Caglayan
  • Mücella Arıkan Yorgun
  • Nilay Yuksel
  • Pınar Kosekahya
  • Cemile Koca
  • Yasin Toklu
Original Paper



The aim of this study was to compare dynamic thiol/disulfide homeostatic status in acute central serous chorioretinopathy (CSCR) patients by using a novel and automated assay determining dynamic thiol/disulfide homeostasis.


Fifty-one patients with acute CSCR (study group) and 65 healthy individuals (control group) were enrolled in this study. Diagnosis of acute CSCR was made clinically and using spectral-domain RTVue OCT (optical coherence tomography) (Optovue, Fremont, CA). Fluorescein angiography confirmed the diagnosis of acute CSCR in all subjects. Total thiol, native thiol, disulfide amount, and native thiol/disulfide ratio (TDR) were calculated in the blood samples.


Mean total thiol, native thiol, and native TDR values were lower in patients with acute CSCR (364.2 ± 14.1, 326.4 ± 13.2, 17.14 ± 1.9, respectively) than in healthy eyes (441.2 ± 16.3, 398.5 ± 16.4, 22.70 ± 2.15, respectively; mean total thiol, p = 0.017; native thiol, p = 0.011; native TDR, p = 0.031).


Total thiol, native thiol, and native TDR were significantly lower statistically in patients with acute CSCR when compared with healthy controls.


Central serous chorioretinopathy Total thiol Native thiol Thiol/disulfide ratio 


Compliance with ethical standards

Conflict of interest

The authors declare no financial or proprietary interests.

Ethical approval

The study protocol followed the principles in the Declaration of Helsinki.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Hasan Altinkaynak
    • 1
  • Piraye Zeynep Kurkcuoglu
    • 2
  • Mehtap Caglayan
    • 1
  • Mücella Arıkan Yorgun
    • 1
  • Nilay Yuksel
    • 1
  • Pınar Kosekahya
    • 4
  • Cemile Koca
    • 3
  • Yasin Toklu
    • 5
  1. 1.Department of OphthalmologyAnkara Atatürk Education and Research HospitalAnkaraTurkey
  2. 2.Department of OphthalmologyWorld Eye HospitalAnkaraTurkey
  3. 3.Department of BiochemistryYıldırım Beyazıt University, Ankara Atatürk Education and Research HospitalAnkaraTurkey
  4. 4.Ulucanlar Eye Education and Research HospitalAnkaraTurkey
  5. 5.Department of OphthalmologyYıldırım Beyazıt University, Ankara Atatürk Education and Research HospitalAnkaraTurkey

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