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Treatment outcome in patients with presumed tubercular uveitis at a tertiary referral eye care centre in Singapore

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Abstract

Aim

To report the clinical features and outcome of patients with presumed tubercular uveitis (TBU).

Methods

Retrospective analysis of patients with presumed TBU at a tertiary referral eye care centre in Singapore between 2007 and 2012 was done. Main outcome measures were failure of complete resolution of uveitis or recurrence of inflammation.

Results

Fifty three patients with mean age of 44.18 ± 15.26 years with 54.72% being males were included. 19 (35.85%) had bilateral involvement, with panuveitis and anterior uveitis being the most common presentations. 36 (67.92%) patients received antitubercular therapy (ATT), and 28 received concurrent systemic steroids. 15 (28.30%) eyes of 11 (30.55%) patients in the ATT group and 4 (21.05%) eyes of 3 (17.64%) patients in the non-ATT group had treatment failure (p value = 0.51).

Conclusion

The use of ATT, with or without concurrent corticosteroid, may not have a statistically significant impact in improving treatment success in patients with presumed TBU.

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Author’s contributions

LA was involved in the conceptualization of the study, data acquisition, analysis of data, and drafting and writing up of the manuscript. AK, YTH, and VGD were involved in the acquisition and analysis of the data. HSL, ST, and RA were involved in conceptualization of the study, writing up and editing of the manuscript.

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Authors and Affiliations

  1. National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, 308433, Singapore

    Leslie Ang, Tun Hang Yeo, Su Ling Ho, Stephen C. Teoh & Rupesh Agrawal

  2. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Aera Kee

  3. Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore

    V. G. Dinesh

  4. Eagle Eye Centre, Singapore, Singapore

    Stephen C. Teoh

Authors
  1. Leslie Ang
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  2. Aera Kee
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  3. Tun Hang Yeo
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  4. V. G. Dinesh
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  5. Su Ling Ho
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  6. Stephen C. Teoh
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  7. Rupesh Agrawal
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Corresponding author

Correspondence to Rupesh Agrawal.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

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Ang, L., Kee, A., Yeo, T.H. et al. Treatment outcome in patients with presumed tubercular uveitis at a tertiary referral eye care centre in Singapore. Int Ophthalmol 38, 11–18 (2018). https://doi.org/10.1007/s10792-016-0401-6

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  • DOI: https://doi.org/10.1007/s10792-016-0401-6

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