International Ophthalmology

, Volume 37, Issue 1, pp 215–219 | Cite as

Occurrence of intraocular air bubbles during intravitreal injections for retinopathy of prematurity

  • Emine Alyamac Sukgen
  • Murat Gunay
  • Yusuf Kocluk
Original Paper


This study aims to present five cases with retinopathy of prematurity (ROP) who were found to have intraocular air bubbles after intravitreal injection (IVI) treatment. The medical records of 148 infants who underwent IVI for ROP were retrospectively reviewed and the ones who demonstrated post-injection intraocular air bubble formation were recruited. Of the 148 patients (31 babies received ranibizumab, 20 babies received aflibercept, 97 babies received bevacizumab), five were found to have intraocular air bubbles right after the IVI. Two infants received intravitreal ranibizumab and three received intravitreal bevacizumab injections. Although intraocular pressure increased temporarily, no intraocular sterile or infective reactions were observed in the postoperative period. The air bubble was found to resorb spontaneously within 72 h. The occurrence rate of the intravitreal air bubbles in our series was 3.37 % despite previously not been reported in the literature. Due to the intravitreal air injection risk, it is important to be more careful while preparing the intravitreal medication before treatment in premature babies.


Bevacizumab Ranibizumab Intravitreal air bubbles Intravitreal treatment Retinopathy of prematurity 



The authors did not receive any financial support from any public or private sources. The authors have no financial or proprietary interest in a product, method or material described herein.


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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Emine Alyamac Sukgen
    • 1
  • Murat Gunay
    • 2
  • Yusuf Kocluk
    • 1
  1. 1.Eye DepartmentAdana Numune Training and Research HospitalAdanaTurkey
  2. 2.Turkish Republic Ministry of Health Zeynep Kamil Gynecology and Pediatrics Education and Research HospitalUskudarTurkey

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