International Ophthalmology

, Volume 36, Issue 5, pp 623–628 | Cite as

Comparative effect of topical diclofenac and topical dexamethasone on anterior chamber flare and postoperative pain following rhegmatogenous retinal detachment surgery

  • Salim Ben YahiaEmail author
  • Rim Kahloun
  • Nesrine Abroug
  • Imene Kaibi
  • Ghassen Laadhari
  • Bechir Jelliti
  • Moncef Khairallah
Original Paper


The purpose of this study is to compare the effect of topical diclofenac and topical dexamethasone on anterior chamber flare and postoperative pain following rhegmatogenous retinal detachment (RRD) surgery. This prospective study included 40 eyes of 40 patients treated for RRD. Twenty-eight patients underwent scleral buckling and 12 patients underwent 20-gauge pars plana vitrectomy (PPV). For each surgical procedure, patients were postoperatively randomly divided into two groups: the first group received topical dexamethasone phosphate 0.1 % four times daily for 28 days; the second group received topical diclofenac sodium 0.1 % three times daily for 28 days. The inflammatory reaction in the anterior chamber was measured with laser flare photometry preoperatively and 1, 7, 14, 28, and 90 days postoperatively. Pain level was evaluated with Scott’s visual analog scale at day 1, 7, 14, and 28 postoperatively. For patients treated with scleral buckling, there was no significant difference between the two groups regarding mean aqueous flare at day 1 (p = 0.096), day 7 (p = 0.435), day 14 (p = 0.510), day 28 (p = 0.583), and day 90 (p = 0.423). The group who received diclofenac had significantly lower pain score at days 7, 14, and 28 (p = 0.048, p = 0.017, and p = 0.028, respectively). For patients treated with PPV, there was no significant difference between the two groups regarding mean aqueous flare at day 1 (p = 0.400), day 7 (p = 0.728), day 14 (p = 0.843), day 28 (p = 0.939), and day 90 (p = 0.568). Patients who received diclofenac had significantly lower pain score at days 7, 14, and 28 (p = 0.032, p = 0.030, and p = 0.023, respectively). Topical diclofenac seems to be as potent as topical dexamethasone in managing postoperative inflammatory response induced by surgery for RRD with better analgesic effect. Both of them are consequences of blood-aqueous barrier and blood-retinal barrier breakdown.


Rhegmatogenous retinal detachment surgery Blood-aqueous barrier Laser flare photometry Postoperative pain Diclofenac Dexamethasone 



This work has been supported by the Ministry of Higher Education and Research of Tunisia.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Salim Ben Yahia
    • 1
    Email author
  • Rim Kahloun
    • 1
  • Nesrine Abroug
    • 1
  • Imene Kaibi
    • 1
  • Ghassen Laadhari
    • 1
  • Bechir Jelliti
    • 1
  • Moncef Khairallah
    • 1
  1. 1.Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of MedicineUniversity of MonastirMonastirTunisia

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