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International Ophthalmology

, Volume 36, Issue 2, pp 207–216 | Cite as

Efficacy of Ozurdex implant in recalcitrant diabetic macular edema—a single-center experience

  • Pooja Bansal
  • Vishali Gupta
  • Amod Gupta
  • Mangat Ram Dogra
  • Jagat Ram
Original Paper

Abstract

The purpose of this study is to report the efficacy of intravitreal Ozurdex implant in managing recalcitrant diabetic macular edema. Retrospective interventional non-randomized study of patients with recalcitrant diabetic macular edema who received intravitreal Ozurdex implant. Main outcome measures were change in the central macular thickness, visual acuity, and intraocular pressure. Sixty-seven eyes of 52 patients with recalcitrant diabetic macular edema with a mean duration of 45.4 ± 22.5 months (range 6–96 months) were studied. Mean central macular thickness decreased from 514.2 ± 177.8 µm at baseline to 394.3 ± 152.2 µm (p = 0.007), 301.8 ± 93.0 µm (p < 0.000), 316.4 ± 115.6 µm (p < 0.000), and 419.9 ± 186.3 µ (p = 0.03) at 1, 6, 12, and 24 weeks, respectively. Mean best corrected visual acuity changed from 0.82 ± 0.46 log MAR to 0. 69 ± 0.44 log MAR (p = 0.122), 0.61 ± 0.40 log MAR (p = 0.007), 0.65 ± 0.37 log MAR (p = 0.024), and 0.68 ± 0.49 log MAR (p = 0.091) at 1, 6, 12, and 24 weeks, respectively. Single injection of intravitreal Ozurdex implant led to progressive decrease in central macular thickness with maximum percentage decrease at 6 weeks (41.2 %) from the baseline which was maintained up to 12 weeks. Eight eyes showed transient rise in intraocular pressure at 2 months which was controlled by antiglaucoma medications.

Keywords

Bevacizumab Dexamethasone intravitreal implant Ozurdex Recalcitrant diabetic macular edema Triamcinolone 

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Pooja Bansal
    • 1
  • Vishali Gupta
    • 1
  • Amod Gupta
    • 1
  • Mangat Ram Dogra
    • 1
  • Jagat Ram
    • 1
  1. 1.Department of Ophthalmology, Advanced Eye CentrePost Graduate Institute of Medical Education and Research (PGIMER)ChandigarhIndia

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