Abstract
The incidence of endophthalmitis after pars plana vitrectomy is low. Silicone oil is a tamponading agent which has anti-microbial activity. Post-operative endophthalmitis following vitrectomy with silicone oil tamponade has been rarely reported. We describe the case of a young male who underwent pars plana vitrectomy with silicone oil for retinal detachment with a giant retinal tear. He developed a clinical picture suggestive of endophthalmitis on the first post-operative day, and vitreous culture grew multidrug-resistant Pseudomonas aeruginosa. He was treated with intravitreal piperacillin/tazobactam, along with appropriate surgical management. This was followed by resolution of the infection with a remarkable improvement in visual acuity. This is the first case of multidrug-resistant Pseudomonas aeruginosa endophthalmitis following pars plana vitrectomy with silicone oil treated successfully with piperacillin/tazobactam.
References
Wu L, Berrocal MH, Arévalo JF et al (2011) Endophthalmitis after pars plana vitrectomy: results of the Pan American Collaborative Retina Study Group. Retina 31:673–678
Eifrig CW, Scott IU, Flynn HW Jr, Smiddy WE, Newton J (2004) Endophthalmitis after pars plana vitrectomy: incidence, causative organisms, and visual acuity outcomes. Am J Ophthalmol 138:799–802
Cohen SM, Flynn HW Jr, Murray TG, Smiddy WE (1995) Endophthalmitis after pars plana vitrectomy. The Postvitrectomy Endophthalmitis Study Group. Ophthalmology 102:705–712
Chong LP, de Juan E, Jr McCuen BW 2nd, Landers MB 3rd (1986) Endophthalmitis in a silicone oil-filled eye. Am J Ophthalmol 102:660–661
Zimmer-Galler IE, Santos A, Haller JA, Campochiaro PA (1997) Management of endophthalmitis in a silicone oil-filled eye. Retina 17:507–509
Ozdamar A, Aras C, Ozturk R, Akin E, Karacorlu M, Ercikan C (1999) In vitro antimicrobial activity of silicone oil against endophthalmitis-causing agents. Retina 19:122–126
Johnson RN, Flynn HW Jr, Parel JM, Portugal LM (1989) Transient hypopyon with marked anterior chamber fibrin following pars plana vitrectomy and silicone oil injection. Arch Ophthalmol 107:683–686
Gin A, Dilay L, Karlowsky JA, Walkty A, Rubinstein E, Zhanel GG (2007) Piperacillin–tazobactam: a beta-lactam/beta-lactamase inhibitor combination. Expert Rev Anti Infect Ther 5:365–383
Ozkiris A, Evereklioglu C, Esel D, Akgün H, Göktas S, Erkiliç K (2005) The efficacy of piperacillin/tazobactam in experimental Pseudomonas aeruginosa endophthalmitis: a histopathological and microbiological evaluation. Curr Eye Res 30:13–19
Singh TH, Pathengay A, Das T, Sharma S (2007) Enterobacter endophthalmitis: treatment with intravitreal tazobactam–piperacillin. Indian J Ophthalmol 55:482–483
Mathai A, Sangwan VS, Pathengay A (2007) Acute postoperative multidrug-resistant Pseudomonas aeruginosa endophthalmitis treated with intravitreal piperacillin/tazobactam. Asian J Ophthalmol 9:185–187
Pathengay A, Mathai A, Shah GY, Ambatipudi S (2010) Intravitreal piperacillin/tazobactam in the management of multidrug-resistant Pseudomonas aeruginosa endophthalmitis. J Cataract Refract Surg 36:2210–2211
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Goel, N., Bhambhwani, V. & Ghosh, B. Multidrug-resistant Pseudomonas aeruginosa endophthalmitis in a silicone oil-filled eye treated with piperacillin/tazobactam: report of a case and review of literature. Int Ophthalmol 35, 599–602 (2015). https://doi.org/10.1007/s10792-015-0072-8
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DOI: https://doi.org/10.1007/s10792-015-0072-8