Clinicopathological study of three cases of infantile fibromatosis of the orbit
We report the clinical and pathological findings in three infants with infantile fibromatosis that involved several extraocular muscles which led to disorders of ocular motility. We also describe their clinical features before and after surgery. This was a retrospective interventional case study with clinicopathological correlations. We present three cases of infantile fibromatosis that were diagnosed by clinical features and histopathlogical examination of biopsy specimens. The three patients were all female children aged 1, 3, and 3 years at their initial visit. The orbital tumor was unilateral in all patients. All three patients had disorders of ocular motility because the tumors involved ≥2 extraocular muscles. The margins between the tumor and the involved extraocular muscles were not distinct. We performed partial resection of the tumors to preserve the extraocular muscles. In all cases, the tumors partially remained, but periodic postoperative magnetic resonance imaging showed no enlargement of the tumors during the follow-up period. All three patients had residual limitations of eye movements. We should consider the postoperative binocular function when we treat infantile benign fibrous tumors involving the extraocular muscles.
KeywordsOrbit Infantile fibromatosis Infantile myofibromatosis Infantile myofibroma Juvenile fibromatosis
The authors thank Dr. Duco I. Hamasaki Professor Emeritus, Bascom Palmer Eye Institute, Department of Ophthalmology University of Miami, School of Medicine Miami, Florida, for his critical discussions and final manuscript revisions.
- 6.Weiss SW, Goldblum JR (2008) Fibrous tumors of infancy and childhood. Enzinger and Weiss’s Soft Tissue Tumors, 5th edn. Mosby, St. Louis, pp 257–302Google Scholar
- 7.Shields JA, Shields CL (2007) Orbital Fibromatosis, Myofibromatosis, and Myofibroma. Eyelid, Conjunctival, and Orbital Tumors: An Atlas and Text. 2nd edn. Lippincott. 622-623Google Scholar
- 14.Coffin CM, Dehner LP, O’Shea PA (1997) Fibroblastic-myofibroblastic tumors. Pediatric Soft Tissue Tumors. Williams & Wilkins, Baltimore, pp 155–161Google Scholar