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Corneal biomechanical characteristics in children with diabetes mellitus

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Abstract

To compare the corneal biomechanical properties in children with type 1 diabetes mellitus (DM) and healthy children. In this cross-sectional study, the study and control groups were composed of 68 children with DM and 74 healthy children, respectively. The corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated intraocular pressure (IOPcc) were measured with the ocular response analyzer (ORA). Associations between ocular and diabetic parameters were also evaluated. There were no statistically significant differences between the two groups in age or gender distribution. The mean CH was 10.8 ± 1.5 and 10.7 ± 1.7 mmHg while the mean CRF was 10.9 ± 1.9 and 10.5 ± 1.6 mmHg in the diabetic group and control group, respectively. The mean IOPg was 15.9 ± 3.7 and 15.2 ± 3.4 mmHg, and the mean IOPcc was 15.8 ± 3.0 and 15.3 ± 3.4 mmHg in the diabetic and control group, respectively. There were no statistically significant differences between the two groups for CH, CRF, IOPg, and IOPcc measurements (independent t test, p = 0.624, p = 0.207, p = 0.263, p = 0.395, respectively). This study shows that type 1 DM does not have any effect on the corneal biomechanical parameters in childhood.

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References

  1. Sánchez-Thorin JC (1998) The cornea in diabetes mellitus. Int Ophthalmol Clin 38:19–36

    Article  PubMed  Google Scholar 

  2. Azar DT, Spurr-Michaud SJ, Tisdale AS, Gipson IK (1989) Decreased penetration of anchoring fibrils into the diabetic stroma. A morphometric analysis. Arch Ophthalmol 107:1520–1523

    Article  CAS  PubMed  Google Scholar 

  3. Azar DT, Spurr-Michaud SJ, Tisdale AS, Gipson IK (1992) Altered epithelial-basement membrane interactions in diabetic corneas. Arch Ophthalmol 110:537–540

    Article  CAS  PubMed  Google Scholar 

  4. Siribunkum J, Kosrirukvongs P, Singalavanija A (2001) Corneal abnormalities in diabetes. J Med Assoc Thai 84:1075–1083

    CAS  PubMed  Google Scholar 

  5. Saghizadeh M, Brown DJ, Castellon R et al (2001) Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Am J Pathol 158:723–734

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Lee JS, Oum BS, Choi HY, Lee JE, Cho BM (2006) Differences in corneal thickness and corneal endothelium related to duration in diabetes. Eye (Lond) 20:315–318

    Article  CAS  Google Scholar 

  7. Ozdamar Y, Cankaya B, Ozalp S, Acaroglu G, Karakaya J, Ozkan SS (2010) Is there a correlation between diabetes mellitus and central corneal thickness? J Glaucoma 19:613–616

    Article  PubMed  Google Scholar 

  8. Larsson LI, Bourne WM, Pach JM, Brubaker RF (1996) Structure and function of the corneal endothelium in diabetes mellitus type I and type II. Arch Ophthalmol 114:9–14

    Article  CAS  PubMed  Google Scholar 

  9. Weston BC, Bourne WM, Polse KA, Hodge DO (1995) Corneal hydration control in diabetes mellitus. Invest Ophthalmol Vis Sci 36:586–595

    CAS  PubMed  Google Scholar 

  10. Ljubimov AV, Huang ZS, Huang GH et al (1998) Human corneal epithelial basement membrane and integrin alterations in diabetes and diabetic retinopathy. J Histochem Cytochem 46:1033–1041

    Article  CAS  PubMed  Google Scholar 

  11. Roszkowska AM, Tringali CG, Colosi P, Squeri CA, Ferreri G (1999) Corneal endothelium evaluation in type I and type II diabetes mellitus. Ophthalmologica 213:258–261

    Article  CAS  PubMed  Google Scholar 

  12. Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813–820

    Article  CAS  PubMed  Google Scholar 

  13. Reddy GK (2003) Glucose-mediated in vitro glycation modulates biomechanical integrity of the soft tissues but not hard tissues. J Orthop Res 21:738–743

    Article  PubMed  Google Scholar 

  14. Wollensak G, Spoerl E, Seiler T (2003) Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg 29:1780–1785

    Article  PubMed  Google Scholar 

  15. Dupps WJ Jr, Netto MV, Herekar S, Krueger RR (2007) Surface wave elastometry of the cornea in porcine and human donor eyes. J Refract Surg 23:66–75

    PubMed Central  PubMed  Google Scholar 

  16. Sady C, Khosrof S, Nagaraj R (1995) Advanced Maillard reaction and crosslinking of corneal collagen in diabetes. Biochem Biophys Res Commun 214:793–797

    Article  CAS  PubMed  Google Scholar 

  17. Kaji Y, Usui T, Oshika T et al (2000) Advanced glycation end products in diabetic corneas. Invest Ophthalmol Vis Sci 41:362–368

    CAS  PubMed  Google Scholar 

  18. Hager A, Wegscheider K, Wiegand W (2009) Changes of extracellular matrix of the cornea in diabetes mellitus. Graefes Arch Clin Exp Ophthalmol 247:1369–1374

    Article  CAS  PubMed  Google Scholar 

  19. Kotecha A, Oddone F, Sinapis C et al (2010) Corneal biomechanical characteristics in patients with diabetes mellitus. J Cataract Refract Surg 36:1822–1828

    Article  PubMed  Google Scholar 

  20. Goldich Y, Barkana Y, Gerber Y et al (2009) Effect of diabetes mellitus on biomechanical parameters of the cornea. J Cataract Refract Surg 35:715–719

    Article  PubMed  Google Scholar 

  21. Sahin A, Bayer A, Ozge G, Mumcuoğlu T (2009) Corneal biomechanical changes in diabetes mellitus and their influence on intraocular pressure measurements. Invest Ophthalmol Vis Sci 50:4597–4604

    Article  PubMed  Google Scholar 

  22. Kara N, Yildirim Y, Univar T, Kontbay T (2012) Corneal biomechanical properties in children with diabetes mellitus. Eur J Ophthalmol. doi:10.5301/ejo.5000196

    Google Scholar 

  23. Broman AT, Congdon NG, Bandeen-Roche K, Quigley HA (2007) Influence of corneal structure, corneal responsiveness, and other ocular parameters on tonometric measurement of intraocular pressure. J Glaucoma 16:581–588

    Article  PubMed  Google Scholar 

  24. Kotecha A (2007) What biomechanical properties of the cornea are relevant for the clinician? Surv Ophthalmol 52(Suppl 2):109–114

    Article  Google Scholar 

  25. Elsheikh A, Wang D, Brown M, Rama P, Campanelli M, Pye D (2007) Assessment of corneal biomechanical properties and their variation with age. Curr Eye Res 32:11–19

    Article  PubMed  Google Scholar 

  26. Luce DA (2005) Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg 31:156–162

    Article  PubMed  Google Scholar 

  27. Tielsch JM, Katz J, Quigley HA, Javitt JC, Sommer A (1995) Diabetes, intraocular pressure, and primary open-angle glaucoma in the Baltimore Eye Survey. Ophthalmology 102:48–53

    Article  CAS  PubMed  Google Scholar 

  28. Klein BE, Klein R, Jensen SC (1994) Open-angle glaucoma and older-onset diabetes. The Beaver Dam Eye Study. Ophthalmology 101:1173–1177

    Article  CAS  PubMed  Google Scholar 

  29. Hennis A, Wu SY, Nemesure B, Leske MC, Barbados Eye Studies Group (2003) Hypertension, diabetes, and longitudinal changes in intraocular pressure. Ophthalmology 110:908–914

    Article  PubMed  Google Scholar 

  30. Dielemans I, de Jong PT, Stolk R, Vingerling JR, Grobbee DE, Hofman A (1996) Primary open-angle glaucoma, intraocular pressure, and diabetes mellitus in the general elderly population. The Rotterdam Study. Ophthalmology 103:1271–1275

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Pınar Nalcacioglu-Yuksekkaya.

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Nalcacioglu-Yuksekkaya, P., Sen, E., Cetinkaya, S. et al. Corneal biomechanical characteristics in children with diabetes mellitus. Int Ophthalmol 34, 881–886 (2014). https://doi.org/10.1007/s10792-014-9899-7

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  • DOI: https://doi.org/10.1007/s10792-014-9899-7

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