Advertisement

International Ophthalmology

, Volume 33, Issue 5, pp 561–565 | Cite as

Localized conjunctival extra-nodal marginal zone B cell lymphoma with presumed paraproteinic crystalline keratopathy

  • Thaer S. Alomar
  • Khalid Mahmood
  • Simon O’Connor
  • Keith Robson
  • Harminder S. Dua
Case Report
  • 114 Downloads

Abstract

Crystalline corneal deposits have been well reported in individual cases of lymphoproliferative disorders associated with hyper-gammaglobulinemia, hence called ‘Crystalline Paraproteinemic Keratopathy’. This is the first report of corneal deposits in a case of localised conjunctival B-cell Lymphoma without paraproteinaemia/hyper-gammaglobulinemia, hence called ‘Presumed Paraproteinic Crystalline Keratopathy’.

Keywords

Paraproteinemic Crystalline keratopathy In vivo confocal microscopy Lymphoma 

References

  1. 1.
    Aronson SB II, Shaw R (1959) Corneal crystals in multiple myeloma. AMA Arch Ophthalmol 61(4):541–546PubMedCrossRefGoogle Scholar
  2. 2.
    Henderson DW et al (1993) Paraproteinemic crystalloidal keratopathy: an ultrastructural study of two cases, including immunoelectron microscopy. Ultrastruct Pathol 17(6):643–668PubMedCrossRefGoogle Scholar
  3. 3.
    Froussart F et al (2001) Corneal crystalline deposits in monoclonal gammapathy: a report of two cases. J Franc Ophtalmol 24(7):738–743Google Scholar
  4. 4.
    Garibaldi DC et al (2005) Immunotactoid keratopathy: a clinicopathologic case report and a review of reports of corneal involvement in systemic paraproteinemias. Surv Ophthalmol 50(1):61–80PubMedCrossRefGoogle Scholar
  5. 5.
    Hutchinson K, Dal Pra M, Apel A (1998) Immunoglobulin G crystalline keratopathy associated with monoclonal gammopathy. Aust N Z J Ophthalmol 26(2):177–179PubMedCrossRefGoogle Scholar
  6. 6.
    Buerk BM, Tu E (2002) Confocal microscopy in multiple myeloma crystalline keratopathy. Cornea 21(6):619–620PubMedCrossRefGoogle Scholar
  7. 7.
    Stirling JW et al (1997) Crystalloidal paraprotein deposits in the cornea: an ultrastructural study of two new cases with tubular crystalloids that contain IgG kappa light chains and IgG gamma heavy chains. Ultrastruct Pathol 21(4):337–344PubMedCrossRefGoogle Scholar
  8. 8.
    Lisch W, Saikia P (2011) Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy and atypical corneal immunoglobulin deposition in a patient with dysproteinemia. Cornea 30(2):247PubMedCrossRefGoogle Scholar
  9. 9.
    Shields CL et al (2001) Conjunctival lymphoid tumors: clinical analysis of 117 cases and relationship to systemic lymphoma. Ophthalmology 108(5):979–984PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Thaer S. Alomar
    • 1
  • Khalid Mahmood
    • 1
  • Simon O’Connor
    • 2
  • Keith Robson
    • 2
  • Harminder S. Dua
    • 1
  1. 1.Division of Ophthalmology and Visual SciencesSchool of Clinical Sciences, Eye ENT Centre, University Hospital, Queens Medical Centre, University of NottinghamNottinghamUK
  2. 2.Department of HistopathologyNottingham University HospitalsNottinghamUK

Personalised recommendations