International Ophthalmology

, Volume 33, Issue 4, pp 415–423 | Cite as

A diagnostic challenge: chronic myelomonocytic leukaemia and recurrent anterior ischaemic optic neuropathy

  • Elisabeth De Smit
  • Eoin O’Sullivan
Case Report


We report the first case of ischaemic optic neuropathy (ION) linked to chronic myelomonocytic leukaemia (CMML) and its associated vasculitis. We discuss the link between CMML and vasculitis and the evidence suggesting it can cause anterior ischaemic optic neuropathy through a vasculitic process. We highlight the difficulty and delay in diagnosis as the use of steroids masked an underlying systemic process. Recurrent ION and raised inflammatory markers should raise suspicion of vasculitis. Together with an elevated monocyte but low platelet count, CMML should be considered.


Vasculitis ANCA Steroids Recurrent Visual Loss Anterior Ischaemic Optic Neuropathy CMML 



Anterior Ischaemic Optic Neuropathy


Arteritic-Anterior Ischaemic Optic Neuropathy


Vasculitis Related-Anterior Ischaemic Optic Neuropathy


Chronic Myelomonocytic Leukaemia


Non-Arteritic Anterior Ischaemic Optic Neuropathy


Myelodysplastic Syndromes



The case was encountered and the work was completed at Croydon University Hospital. The authors have no proprietary or commercial interest in any of the materials displayed in this case report.

Conflict of interest

The authors have no conflict of interest


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Eye UnitCroydon University HospitalCroydonUK

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