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International Ophthalmology

, Volume 32, Issue 1, pp 1–2 | Cite as

Surgical intervention for corneal involvement in xeroderma pigmentosa

  • Sunita Chaurasia
  • Muralidhar Ramappa
Letter to the Editor

Xeroderma pigmentosum (XP) is a rare autosomal recessive genetic disorder characterized by solar injury to exposed skin and ocular tissues due to an enzymatic defect in the ability to repair DNA damage caused by ultraviolet (UV) light [1]. The cornea in XP may show dryness, haze, exposure keratitis, vascularization, and opacification [2].

Most patients present to the cornea clinic with a significantly scarred cornea which requires corneal transplantation for visual rehabilitation. In such cases, corneal surgeons are faced with the dilemma of performing penetrating keratoplasty (PK) versus lamellar keratoplasty (LK). Anterior LK is preferred over PK for management of corneal opacity as it eliminates the risk of endothelial rejection. The few reports on the outcomes of PK in XP are encouraging, but the feasibility and results of anterior LK in XP patients is not available in the literature.

According to the only reported in vivo study of corneal endothelium in XP, the patients were found...

Keywords

Xeroderma Pigmentosum Corneal Endothelium Corneal Edema Penetrate Keratoplasty Deep Anterior Lamellar Keratoplasty 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgement

The authors would like to thank Hyderabad Eye Research Foundation and Hyderabad Eye Institute

Conflict of interest

None.

References

  1. 1.
    Kraemer KH, Lee MM, Scotto J (1987) Xeroderma pigmentosum. Cutaneous, ocular and neurologic abnormalities in 830 published cases. Arch Dermatol 123:241PubMedCrossRefGoogle Scholar
  2. 2.
    Sevel D (1963) Xeroderma pigmentosum with ocular complications. Br J Ophthal 47:687–689CrossRefGoogle Scholar
  3. 3.
    Okubo K, Nakamura M, Nomura K et al (1987) The corneal endothelium in xeroderma pigmentosum. Ophthalmologica 195(4):178–182PubMedCrossRefGoogle Scholar
  4. 4.
    Kanavi MR, Javadi MA, Yeganeh HRZ (2008) Corneal involvement in xeroderma pigmentosum; a histopathologic report. J Ophthalmic Vis Res 3(1):66–69Google Scholar
  5. 5.
    Podskochy A, Gan L, Fagerholm P (2000) Apoptosis in UV-exposed rabbit cornea. Cornea 19(1):99–103PubMedCrossRefGoogle Scholar
  6. 6.
    Nagy ZZ, Seitz B, Maldonado MJ et al (1995–1996) Changes of the corneal endothelium after ultraviolet-B exposure in previously photokeratectomised eyes. Acta Chir Hung 35(3–4):325–32Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Cornea and Anterior Segment ServicesLV Prasad Eye Institute, Kallam Anji Reddy CampusHyderabadIndia

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