Effect of pan retinal photocoagulation on the serum levels of vascular endothelial growth factor in diabetic patients
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This study tests the hypothesis that subjects with proliferative diabetic retinopathy (PDR) have a detectable rise in levels of serum vascular endothelial growth factor (VEGF), which is an important regulator of angiogenesis. Our investigation aims to evaluate plasma VEGF changes after pan-retinal photocoagulation (PRP) in diabetic patients. Twenty-nine type two diabetic patients (17 male, 12 female: mean age 53.13 ± 12.22 years) with PDR secondary to diabetes were studied. Blood samples were obtained before and at 2 months after the last PRP session. Serum VEGF levels were measured by ELISA. After PRP, the mean serum VEGF decreased, but this reduction was not remarkable (88.68 ± 71.09 vs. 77.01 ± 60.33 ng/ml) (P = 0.18). There was a statistically significant difference in serum VEGF changes between patients who had regressed PDR with patients who had progressed PDR (−25.98 ± 47.37 vs. 56.44 ± 31.7 ng/ml) (P = 0.003). Our results showed a significant reduction in levels of serum VEGF in the patients who had successful laser treatment. Our findings suggest that serum VEGF levels could be used for monitoring diabetic retinopathy outcome.
KeywordsType 2 diabetes Proliferative diabetic retinopathy Vascular endothelial growth factor Pan retinal photocoagulation
This study was supported by Yazd diabetes Research Center of Shahid Sadoughi University of Medical Sciences. The authors wish to thank all the colleagues who supported the research, especially Laila Azod for assistance with sampling.
No competing financial interests exist.
- 10.Lip PL, Belgore F, Blann AD, Hope-Ross MW, Gibson JM, Lip GYH (2000) Plasma VEGF and soluble VEGF receptor FLT-1 in proliferative retinopathy: relationship to endothelial dysfunction and laser treatment. Investig Ophthalmol Vis Sci 41(8):2115Google Scholar
- 11.Shinoda K, Ishida S, Kawashima S, Wakabayashi T, Matsuzaki T, Takayama M et al (1999) Comparison of the levels of hepatocyte growth factor and vascular endothelial growth factor in aqueous fluid and serum with grades of retinopathy in patients with diabetes mellitus. Br J Ophthalmol 83(7):834PubMedCrossRefGoogle Scholar
- 13.Manaviat MR, Rashidi M, Afkhami-Ardekani M (2008) Four years incidence of diabetic retinopathy and effective factors on its progression in type II diabetes. Eur J Ophthalmol 18:1521–1522Google Scholar
- 21.Emani S, Ramlawi B, Sodha NR, Li J, Bianchi C, Sellke FW (2009) Increased vascular permeability after cardiopulmonary bypass in patients with diabetes is associated with increased expression of vascular endothelial growth factor and hepatocyte growth factor. J Thorac Cardiovasc Surg 138(1):185–191PubMedCrossRefGoogle Scholar