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International Ophthalmology

, Volume 30, Issue 6, pp 697–702 | Cite as

Intravitreal bevacizumab for persistent macular edema with proliferative diabetic retinopathy

  • Gokhan Gulkilik
  • Muhittin Taskapili
  • Selim Kocabora
  • Gulipek Muftuoglu
  • Goktug Demirci
Article

Abstract

To evaluate the effectiveness of an intravitreal bevacizumab injection on retinal neovascularization and diabetic macular edema (DME) refractory to laser photocoagulation therapy. Thirty-four eyes of 22 patients with proliferative diabetic retinopathy and DME refractory to laser photocoagulation therapy received an intravitreal injection of 1.25 mg/0.05 ml of bevazicumab. Changes in mean best-corrected visual acuity (BCVA), central macular thickness (CMT), regression of neovascularization over time, and correlation between BCVA and CMT were evaluated. Follow-up visits were at weeks 1, 2 and 4 and months 3 and 6. Mean BCVA was significantly better than baseline only at week 2 (P = 0.036). Mean CMT decreased significantly from baseline at weeks 1, 2, and 4 (P = 0.001). At months 3 and 6, mean CMT increased, albeit insignificantly (P = 0.804 and P = 1.0). The decrease in fluorescein leakage was moderate in all eyes at the end of week 1. At week 2, there was total resolution of fluorescein leakage in 24 (70.5%) eyes and moderate resolution in 10 (29.5%) eyes. At the end of month 3, the fluorescein leakage was fully resolved in 5 (14.7%) eyes, moderately resolved in 24 (70.5%) eyes, and was similar to baseline in 5 (14.7%) eyes. At month 6, the fluorescein leakage was fully resolved in 3 (8.8%) eyes, moderately resolved in 20 (58.8%) eyes, and was similar to baseline in 11 (32.4%) eyes. A moderate but insignificant negative correlation was found between visual acuity and CMT (P > 0.05). Persistence or recurrence of neovascular tissue after panretinal photocoagulation may be attributed to the production of vascular endothelial growth factor by the residual ischemic retina, which also results in persistent or recurrent DME despite macular grid photocoagulation.

Keywords

Bevacizumab Diabetic retinopathy Macular edema Neovascularization 

Notes

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Gokhan Gulkilik
    • 1
  • Muhittin Taskapili
    • 2
  • Selim Kocabora
    • 2
  • Gulipek Muftuoglu
    • 3
  • Goktug Demirci
    • 4
  1. 1.Sisli Etfal Education and Research Hospital, Eye ClinicYesilkoy-IstanbulTurkey
  2. 2.Vakif Gureba Education Hospital, Eye ClinicIstanbulTurkey
  3. 3.Department of Ophthalmology, Cerrahpasa Medical FacultyIstanbul UniversityIstanbulTurkey
  4. 4.Department of OphthalmologyDuzce Government HospitalDuzceTurkey

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