Skip to main content

Advertisement

SpringerLink
Log in

Choroidal granuloma as an initial manifestation of systemic sarcoidosis

  • Case Report
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Systemic sarcoidosis presenting as a choroidal nodule is a rare phenomenon, with limited reports in the past. We present a case of systemic sarcoidosis in a young adult male presenting as a solitary choroidal mass. The diagnosis was made based on elevated serum lysozyme, serum angiotensin-converting enzyme, negative Mantoux, and computed tomography (CT) scan of the chest. Ultrasound examination and fundus fluorescein angiography helped us to differentiate this lesion from choroidal melanoma. Magnetic resonance imaging (MRI) of brain was done to rule out neurosarcoidosis. Patient responded well to systemic steroid therapy, with marked resolution of the choroidal granuloma, and reduced size of mediastinal lymph nodes on repeat CT scan of the chest.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Letocha CE, Shields JA, Goldberg RE (1975) Retinal changes in sarcoidosis. Can J Ophthalmol 10:184–192

    CAS  PubMed  Google Scholar 

  2. Ozazewski JC, Bennett V (1952) Ocular sarcoidosis. Report of three cases. Am J Ophthalmol 35:547–550

    CAS  PubMed  Google Scholar 

  3. Olk RJ, Lipmann MJ, Cundiff HC, Daniels J (1983) Solitary choroidal mass as the presenting sign in systemic sarcoidosis. Br J Ophthalmol 6:826–829. doi:10.1136/bjo.67.12.826

    Article  Google Scholar 

  4. Tingey DP, Gonder JR (1992) Ocular sarcoidosis presenting as a solitary choroidal mass. Can J Ophthalmol 27:25–29

    CAS  PubMed  Google Scholar 

  5. Stanbury RM, Graham EM, Murray PI (1995) Sarcoidosis. Int Ophthalmol Clin 35:123–137. doi:10.1097/00004397-199503530-00010

    Article  CAS  PubMed  Google Scholar 

  6. Obenauf CD, Shaw HE, Sydnor CF, Klintworth GK (1978) Sarcoidosis and its ophthalmic manifestations. Am J Ophthalmol 86:648–655

    CAS  PubMed  Google Scholar 

  7. Dufay-Dupar B, Soubrane G, Ortonne N (2006) Choroidal white dots and sarcoidosis. J Fr Ophtalmol 29:e23

    CAS  PubMed  Google Scholar 

  8. Gould H, Kaufman HE (1961) Sarcoid of the fundus. Arch Ophthalmol 65:453–456

    CAS  PubMed  Google Scholar 

  9. Kawaguchi T, Hanada A, Horie S, Sugamoto Y, Sugita S, Mochizuki M (2007) Evaluation of characteristic ocular signs and systemic investigations in ocular sarcoidosis patients. Jpn J Ophthalmol 51:121–126. doi:10.1007/s10384-006-0413-2

    Article  PubMed  Google Scholar 

  10. Desai UR, Tawansy KA, Joondeph BC, Schiffman RM (2001) Choroidal granulomas in systemic sarcoidosis. Retina 21:40–47. doi:10.1097/00006982-200102000-00007

    Article  CAS  PubMed  Google Scholar 

  11. Heck AW, Phillips LH II (1989) Sarcoidosis and the nervous system. Neurol Clin 7:641–654

    CAS  PubMed  Google Scholar 

  12. Rouberol F, Duquesne N, Kodjikian L, Guerillon F, Grange JD (2002) Sarcoid granuloma simulating amelanotic melanoma of the iris: a case report. J Fr Ophtalmol 25:831–834

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ocular Pathology, Medical Research Foundation, Sankara Nethralaya, 18, College Road, Chennai, 600006, India

    Aditya Verma & Jyotirmay Biswas

Authors
  1. Aditya Verma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jyotirmay Biswas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Aditya Verma.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Verma, A., Biswas, J. Choroidal granuloma as an initial manifestation of systemic sarcoidosis. Int Ophthalmol 30, 603–606 (2010). https://doi.org/10.1007/s10792-009-9328-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-009-9328-5

Keywords

Search

Navigation