International Ophthalmology

, Volume 30, Issue 3, pp 307–310 | Cite as

Descemet’s stripping endothelial keratoplasty: is it an option for congenital hereditary endothelial dystrophy?

  • Roberto PinedaII
  • Vandana Jain
  • Debraj Shome
  • David C. Hunter
  • Sundaram Natarajan
Case Report


The purpose of this study was to report our experience of an attempted Descemet’s stripping automated endothelial keratoplasty (DSAEK) in a patient with congenital hereditary endothelial dystrophy (CHED). A 7-year-old boy presented with the complaints of decreased vision in his right eye. The left eye had undergone penetrating keratoplasty at the age of 5 years. He was diagnosed as a case of CHED, and a DSAEK was planned for him. Due to technical difficulties during Descemet’s membrane scoring and stripping and poor visualization, the procedure had to be abandoned and converted to a full thickness penetrating keratoplasty. To the best of our knowledge, this is the first reported case of an attempted DSAEK in a patient with CHED. Proper DSAEK case selection should include adequate visualization of the endothelium and anterior chamber. Severe stromal haze and edema may prevent necessary surgical observation during the procedure, and a full thickness penetrating keratoplasty may be required.


CHED DSAEK Penetrating keratoplasty 



This research was financially supported by Aditya Jyot Research Foundation, Dadar, Mumbai, India.


  1. 1.
    Graham MA, Azar NF, Dana MR (2001) Visual rehabilitation in children with congenital hereditary endothelial dystrophy. Int Ophthalmol Clin 4:9–18CrossRefGoogle Scholar
  2. 2.
    Dana MR, Moyes AL, Gomes JA et al (1995) The indications for and outcome in pediatric keratoplasty. A multicenter study. Ophthalmology 102:1129–1138PubMedGoogle Scholar
  3. 3.
    Gorovoy MS (2006) Descemet stripping automated endothelial keratoplasty (DSAEK). Cornea 25:886–889CrossRefPubMedGoogle Scholar
  4. 4.
    Price MO, Price FW (2007) Descemet’s stripping endothelial keratoplasty. Curr Opin Ophthalmol 18:290–294CrossRefPubMedGoogle Scholar
  5. 5.
    Allan BD, Terry MA, Price FW et al (2007) Corneal transplant rejection rate and severity after endothelial keratoplasty. Cornea 26:1039–1042CrossRefPubMedGoogle Scholar
  6. 6.
    Price MO, Price FW Jr (2007) Descemet’s stripping endothelial keratoplasty for treatment of iridocorneal endothelial syndrome. Cornea 26:493–497CrossRefPubMedGoogle Scholar
  7. 7.
    Culbertson WW (2006) Descemet’s stripping endothelial keratoplasty. Int Ophthalmol Clin 46:155–168CrossRefPubMedGoogle Scholar
  8. 8.
    Price FW Jr, Price MO (2005) Descemet’s stripping with endothelial keratoplasty in 50 eyes; a refractive neutral cornea transplant. J Refract Surg 21:339–345PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Roberto PinedaII
    • 1
  • Vandana Jain
    • 2
  • Debraj Shome
    • 3
    • 4
  • David C. Hunter
    • 5
  • Sundaram Natarajan
    • 6
  1. 1.Department of CorneaMassachusetts Eye and Ear InfirmaryBostonUSA
  2. 2.Department of Cornea and External DiseasesAditya Jyot Eye HospitalMumbaiIndia
  3. 3.Department of Ophthalmic and Facial Plastic Surgery, Orbital Diseases, and Ocular OncologyAditya Jyot Eye HospitalMumbaiIndia
  4. 4.Department of Ocular OncologyTata Memorial CentreMumbaiIndia
  5. 5.Orbis Flying Eye HospitalNew YorkUSA
  6. 6.Department of RetinaAditya Jyot Eye HospitalMumbaiUSA

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