Probiotic mixture of Lactobacillus and Bifidobacterium alleviates systemic adiposity and inflammation in non-alcoholic fatty liver disease rats through Gpr109a and the commensal metabolite butyrate

  • Yinji Liang
  • Chenli Lin
  • Yupei Zhang
  • Yuanjun Deng
  • Chan Liu
  • Qinhe Yang
Short Communication

Abstract

Aims

The study explored the systemic adiposity and inflammation through Gpr109a and the commensal metabolite butyrate during the treatment of non-alcoholic fatty liver disease rats with the probiotic mixture of Lactobacillus and Bifidobacterium for 16 weeks.

Methods

Fifteen male SD rats were randomly divided into three groups of five rats each: normal control group (basal feed), high-fat diet (HFD) feeding group (83% basal feed + 10% lard oil + 5% sucrose + 1.5% cholesterol + 0.5% cholate), and probiotic mixture intervention group (HFD + 0.6 g kg−1 day−1 probiotic mixture). Body composition, serum lipids, serum inflammatory markers, Gpr109a, and the commensal metabolite butyrate were assessed.

Results

Compared with HFD group, probiotic mixture significantly reduced body weight and the levels of serum FFA, TG, ALT, IL-1β, and IL-18 (P < 0.05). The levels of Gpr109a and the commensal metabolite butyrate also changed significantly (P < 0.05).

Conclusions

Probiotic mixture might inhibit systemic adiposity and inflammation through Gpr109a and the commensal metabolite butyrate in response to the insult of HFD.

Keywords

Non-alcoholic fatty liver disease Probiotics Gpr109a Adiposity Inflammation 

Notes

Acknowledgements

This work was supported in part by the National Natural Science Foundation of China (Nos. 81774165 and 81573844), the Natural Science Foundation of Guangdong in China (No. 2016A030313824), the Traditional Chinese Medicine Bureau of Guangdong in China (No. 20161065), and the National Health and Family Planning Commission of Guangdong in China (Nos. A2016583 and A2017228).

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of NursingJinan UniversityGuangzhouChina
  2. 2.School of Basic MedicineJinan UniversityGuangzhouChina
  3. 3.School of Traditional Chinese MedicineJinan UniversityGuangzhouChina

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