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Oxidative stress as a possible mechanism of statin-induced myopathy

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Abstract

Statins, inhibitors of hydroxy methyl glutaryl coenzyme-A (HMG-CoA) reductase, are the most widely used drugs for treating hypercholesterolemia. However, statins can cause disabling myopathy as their main adverse effect. Several molecular mechanisms underlie the statin-induced myopathy including the decrease in the levels of essential mevalonate and cholesterol derivatives. This review discusses a further mechanism involving the loss of other anti-oxidant defenses besides ubiquinone (Co-Q) in skeletal muscles which produce a significant amount of reactive oxygen species (ROS). Therefore, to maintain their function, skeletal muscles need a high level of anti-oxidants.

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Fig. 1
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Data was obtained from “TiGER: A database for tissue-specific gene expression and regulation” for homosapiens

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Authors and Affiliations

  1. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Yasin Ahmadi

  2. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Yasin Ahmadi & Amir Ghorbanihaghjo

  3. Department of Biochemistry and Clinical Laboratories, Tehran University of Medical Sciences, Tehran, Iran

    Mohsen Naghi-Zadeh

  4. Nutritional Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Neda Lotfi Yagin

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Ahmadi, Y., Ghorbanihaghjo, A., Naghi-Zadeh, M. et al. Oxidative stress as a possible mechanism of statin-induced myopathy. Inflammopharmacol 26, 667–674 (2018). https://doi.org/10.1007/s10787-018-0469-x

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