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Inflammopharmacology

, Volume 26, Issue 3, pp 667–674 | Cite as

Oxidative stress as a possible mechanism of statin-induced myopathy

  • Yasin Ahmadi
  • Amir Ghorbanihaghjo
  • Mohsen Naghi-Zadeh
  • Neda Lotfi Yagin
Review

Abstract

Statins, inhibitors of hydroxy methyl glutaryl coenzyme-A (HMG-CoA) reductase, are the most widely used drugs for treating hypercholesterolemia. However, statins can cause disabling myopathy as their main adverse effect. Several molecular mechanisms underlie the statin-induced myopathy including the decrease in the levels of essential mevalonate and cholesterol derivatives. This review discusses a further mechanism involving the loss of other anti-oxidant defenses besides ubiquinone (Co-Q) in skeletal muscles which produce a significant amount of reactive oxygen species (ROS). Therefore, to maintain their function, skeletal muscles need a high level of anti-oxidants.

Keywords

Cholesterol Myopathy Oxidative stress Statins Ubiquinone 

Notes

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. 1.Student Research CommitteeTabriz University of Medical SciencesTabrizIran
  2. 2.Biotechnology Research CenterTabriz University of Medical SciencesTabrizIran
  3. 3.Department of Biochemistry and Clinical LaboratoriesTehran University of Medical SciencesTehranIran
  4. 4.Nutritional Research CenterTabriz University of Medical SciencesTabrizIran

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