Overexpression of uncoupling protein-2 in cancer: metabolic and heat changes, inhibition and effects on drug resistance
- 231 Downloads
This paper deals with the role of uncoupling protein-2 (UCP2) in cancer. UCP2 is overexpressed in cancer. This overexpression results in uncoupling of mitochondrial oxidative phosphorylation and a shift in production of ATP from mitochondrial oxidative phosphorylation to cytosolic aerobic glycolysis. UCP2 overexpression results in the following changes. Mitochondrial membrane potential (Δψ m) is decreased and lactate accumulates. There is a diminished production of reactive oxygen species and apoptosis is inhibited post-exposure to chemotherapeutic agents. There is an increase in heat and entropy production and a departure from the stationary state of non-cancerous tissue. Uncoupling of oxidative phosphorylation may also be caused by protonophores and non-steroidal anti-inflammatory drugs. UCP2 requires activation by superoxide and lipid peroxidation derivatives. As vitamin E inhibits lipid peroxidation, it might be expected that vitamin E would act as a chemotherapeutic agent against cancer. A recent study has shown that vitamin E and another anti-oxidant accelerate cancer progression. UCP2 is inhibited by genipin, chromane compounds and short interfering RNAs (siRNA). Genipin, chromanes and siRNA are taken up by both cancer and non-cancerous cells. Targeting the uptake of these agents by cancer cells by the enhanced permeability and retention effect is considered. Inhibition of UCP2 enhances the action of several anti-cancer agents.
KeywordsCancer Uncoupling protein-2 overexpression Uncoupling protein-2 inhibition Non-steroidal anti-inflammatory drugs Vitamin E Uncoupling protein-2 inhibition effect on chemotherapeutic agents
Compliance with ethical standards
Conflict of interest
The author, Dr Michael A Pitt, states that there is no actual, potential or perceived conflict of interest in regard to this paper.
- Julienne CM, Duma J-F, Goupille C, Pinault M, Berri C, Collin A, Tesseraud S, Couet C, Servais S (2012) Cancer cachexia is associated with a decrease in skeletal muscle mitochondrial oxidative capacities without alteration of ATP production efficiency. J Cachexia Sarcopenia Muscle 3:265–275PubMedCentralCrossRefPubMedGoogle Scholar
- Kondepudi D, Prigogine I (1998) Modern thermodynamics: from heat engines to dissipative structures. Wiley, ChichesterGoogle Scholar
- Moreno-Sánchez R, Vásquez C, Ayala G, Silveira LH, Martínez-Lavin M (1999) Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart. Biochem Pharmacol 57:743–752CrossRefPubMedGoogle Scholar
- Stefanadis C, Chrysochoou C, Markou D, Petraki K, Panagiotakos DB, Fasoulakis C, Kyriakidis A, Papadimitriou C, Toutouzas PK (2001) Increased temperature of malignant urinary bladder tumors in vivo: the application of a new method based on a catheter technique. J Clin Oncol 19:676–681PubMedGoogle Scholar