Advertisement

Inflammopharmacology

, Volume 16, Issue 4, pp 188–194 | Cite as

Differential protein expression induced by a lipid extract of Perna canaliculus in splenocytes of rats with adjuvant-induced arthritis

  • C.-H. Lee
  • Y. K.-C. Butt
  • M.-S. Wong
  • S. C.-L. Lo
Research Article

Abstract.

The lipid extract of Perna canaliculus (Lyprinol®) has known anti-inflammatory effects. However, the only information on mechanisms is regulation of cytokine secretion. Therefore, we conducted a proteomic study exploring the effects of Lyprinol on protein expression in splenocytes collected from AIA rats. Splenocytes from AIA rats fed with Lyprinol had increased protein expression of malate dehydrogenase (MDH). Lyprinol also decreased the expressions of 5 other proteins: protein-o-mannosyl- transferase 2 (PMT-2), Tdrd 7, telethonin, dynactin 2 and protein disulfide isomerase (PDI or glucose-regulated protein (GRP)). Besides MDH, PMT- 2, titin-cap protein and protein disulfide isomerase (PDI) are known to be related to metabolism. However, it is currently unknown if Lyprinol administration decreases metabolic glucose in the body and alleviates symptoms of inflammation and arthritis. Further experiments are required to correlate levels of citric acid intermediates and glucose to the severity of inflammation and pain in AIA rats fed Lyprinol.

Keywords:

Lyprinol Adjuvant-induced arthritis Proteomics Malate dehydrogenase Protein disulfide isomerase Protein-o-mannoyl-transferase Titin-cap protein Tdrd7 protein 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer 2008

Authors and Affiliations

  • C.-H. Lee
    • 1
    • 2
  • Y. K.-C. Butt
    • 1
    • 2
  • M.-S. Wong
    • 1
    • 2
  • S. C.-L. Lo
    • 1
    • 2
  1. 1.Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHung Hom, KowloonHong Kong SAR
  2. 2.China and State Key Laboratory of Chinese Medicine and Molecular PharmacologyShenzhenChina

Personalised recommendations