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Colloidal metallic gold is not bio-inert

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Inflammopharmacology Aims and scope Submit manuscript

Abstract.

Metallic gold (Au°) is a likely biotransformation product of monovalent gold, Au(I) whenever it is dissociated from in vivo ligands, Au° being formed either by bioreduction or by spontaneous dismutation (with co-production of trivalent gold). This review discusses the preparation and some biologically relevant properties of colloidal metallic gold (CMG) in its nano-particulate form. Tyndall’s purple, a well characterised preparation of CMG, shows potent anti-arthritic activity in rats, approximately 103 times that of sodium aurothiomalate (Myocrysin). Even more remarkable is its broader spectrum of action in rats compared to this classic DMARD.

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Authors and Affiliations

  1. Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Science, Griffith University, Nathan Campus, Brisbane, Qld., 4111, Australia

    C. L. Brown, M. W. Whitehouse, E. R. T. Tiekink & G. R. Bushell

Authors
  1. C. L. Brown
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  2. M. W. Whitehouse
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  3. E. R. T. Tiekink
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  4. G. R. Bushell
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Corresponding author

Correspondence to C. L. Brown.

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This article is dedicated to the memory of Michael Faraday (1791–1867), the father of electromagnetism and a truly remarkable chemist.

Received 4 July 2007; accepted 10 September 2007

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Brown, C.L., Whitehouse, M.W., Tiekink, E.R.T. et al. Colloidal metallic gold is not bio-inert. Inflammopharmacol 16, 133–137 (2008). https://doi.org/10.1007/s10787-007-0017-6

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  • DOI: https://doi.org/10.1007/s10787-007-0017-6

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