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Inflammopharmacology

, Volume 16, Issue 3, pp 133–137 | Cite as

Colloidal metallic gold is not bio-inert

  • C. L. Brown
  • M. W. Whitehouse
  • E. R. T. Tiekink
  • G. R. Bushell
Review

Abstract.

Metallic gold (Au°) is a likely biotransformation product of monovalent gold, Au(I) whenever it is dissociated from in vivo ligands, Au° being formed either by bioreduction or by spontaneous dismutation (with co-production of trivalent gold). This review discusses the preparation and some biologically relevant properties of colloidal metallic gold (CMG) in its nano-particulate form. Tyndall’s purple, a well characterised preparation of CMG, shows potent anti-arthritic activity in rats, approximately 103 times that of sodium aurothiomalate (Myocrysin). Even more remarkable is its broader spectrum of action in rats compared to this classic DMARD.

Keywords

Gold Nanoparticles Colloidal Gold Pristane Metallic Gold Dark Agouti 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • C. L. Brown
    • 1
  • M. W. Whitehouse
    • 1
  • E. R. T. Tiekink
    • 1
  • G. R. Bushell
    • 1
  1. 1.Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical ScienceGriffith UniversityBrisbaneAustralia

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