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InflammoPharmacology

, Volume 14, Issue 5–6, pp 204–206 | Cite as

DNA hypermethylation in colorectal neoplasms and inflammatory bowel disease: a mini review

  • O. Maeda
  • T. Ando
  • O. Watanabe
  • K. Ishiguro
  • N. Ohmiya
  • Y. Niwa
  • H. Goto
Review

Abstract.

DNA hypermethylation is one of major epigenetic changes. Hypermethylation of many genes has been reported to be related with carcinogenesis and tumor progression of colorectal cancer. Some genes including estrogen receptor is associated with ageing, and changes related with ageing may be accelerated in inflammatory bowel disease. Furthermore, fecal DNA methylation will be able to be used as a marker of colorectal cancer and inflammatory bowel disease. Evaluation of hypermethylation potentially contributes diagnosis of colorectal diseases.

Key words.

Hypermethylation Inflammatory bowel disease Colorectal cancer Fecal DNA 

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Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  • O. Maeda
    • 1
  • T. Ando
    • 1
  • O. Watanabe
    • 1
  • K. Ishiguro
    • 1
  • N. Ohmiya
    • 1
  • Y. Niwa
    • 1
  • H. Goto
    • 1
  1. 1.Department of GastroenterologyNagoya University Graduate School of MedicineNagoyaJapan

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