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Inflammopharmacology

, Volume 15, Issue 1, pp 31–35 | Cite as

Changes in evaluation of the pepsinogen test result following Helicobacter pylori eradication therapy in Japan

  • T. Kawai
  • K. Miki
  • M. Ichinose
  • Y. Kenji
  • I. Miyazaki
  • K. Kawakami
  • M. Kataoka
  • T. Yamagishi
  • A. Sofuni
  • T. Itoi
  • F. Moriyasu
  • Y. Takagi
  • T. Aoki
  • J. Matsubayashi
  • K. Mukai
Research Article

Abstract.

Aims

The pepsinogen (PG) test result is used in Japan for screening for gastric cancer. In this study, we investigated the changes in evaluation of the PG test result following H. pylori eradication.

Methods

The subjects were 120 consecutive H. pylori-positive patients with upper gastrointestinal symptoms. Subjects underwent endoscopy prior to, and at 2 months after the eradication therapy, at which time blood was taken for determination of changes in PG levels.

Results

The overall eradication rate was 79.3 % (per protocol). Following eradication therapy, the evaluation of PG test result converted from positive to negative in 80.4 % (37/46) of cases of successful eradication, and in 0 % (0/6) of cases of eradication failure.

Conclusions

These results suggest that the evaluation of PG test result should be used after the definitive confirmation of the success or failure of H. pylori eradication therapy.

Keywords.

Eradication Helicobacter pylori Pepsinogen 

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Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  • T. Kawai
    • 1
  • K. Miki
    • 5
  • M. Ichinose
    • 6
  • Y. Kenji
    • 2
  • I. Miyazaki
    • 2
  • K. Kawakami
    • 2
  • M. Kataoka
    • 1
  • T. Yamagishi
    • 1
  • A. Sofuni
    • 2
  • T. Itoi
    • 2
  • F. Moriyasu
    • 2
  • Y. Takagi
    • 3
  • T. Aoki
    • 3
  • J. Matsubayashi
    • 4
  • K. Mukai
    • 4
  1. 1.Endoscopy CenterTokyo Medical University HospitalTokyoJapan
  2. 2.Fourth Department of Internal MedicineTokyo Medical UniversityTokyoJapan
  3. 3.Third Department of SurgeryTokyo Medical UniversityTokyoJapan
  4. 4.Department of PathologyTokyo Medical University HospitalTokyoJapan
  5. 5.Division of Gastroenterology & Hepatology, Department of Internal Medicine (Ohmori)School of Medicine of Faculty of Medicine Toho UniversityTohoJapan
  6. 6.Second department of Internal MedicineWakayama Medical UniversityWakayamaJapan

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