Solubility Determination and Modeling and Dissolution Thermodynamic Properties of Raspberry Ketone in Binary Solvent Mixtures of Ethanol and Water

  • Min Shu
  • Liang Zhu
  • Yan-fei Wang
  • Jing Yang
  • Liyu Wang
  • Libin Yang
  • Xiaoyu Zhao
  • Wei Du
Article
  • 67 Downloads

Abstract

The solubility and dissolution thermodynamic properties of raspberry ketone in a set of binary solvent mixtures (ethanol + water) with different compositions were experimentally determined by static gravimetrical method in the temperature range of 283.15–313.15 K at 0.10 MPa. The solubility of raspberry ketone in this series of ethanol/water binary solvent mixtures was found to increase with a rise in temperature and the rising mole fraction of ethanol in binary solvent mixtures. The van’t Hoff, modified Apelblat and 3D Jouyban–Acree–van’t Hoff equations were increasingly applied to correlate the solubility in ethanol/water binary solvent mixtures. The former two models could reach better fitting results with the solubility data, while the 3D model can be comprehensively used to estimate the solubility data in all the ratios of ethanol and water in binary solvent mixtures at random temperature. Furthermore, the changes of dissolution thermodynamic properties of raspberry ketone in experimental ethanol/water solvent mixtures were obtained by van’t Hoff equation. For all the above experiments, these dissolution processes of raspberry ketone in experimental ethanol/water binary solvent mixtures were estimated to be endothermic and enthalpy-driven.

Keywords

3D Jouyban–Acree–van’t Hoff model Binary solvent mixtures Dissolution thermodynamic properties Gravimetric method Raspberry ketone Solubility 

Notes

Acknowledgements

The financial support of the Tianjin Research Program of Application Foundation and Advanced Technology (Grant No. 14JCZDJC40900) and the National Natural Science Foundation of China (Grant No. 21506162) are sincerely acknowledged.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Min Shu
    • 1
  • Liang Zhu
    • 1
  • Yan-fei Wang
    • 1
  • Jing Yang
    • 1
  • Liyu Wang
    • 1
  • Libin Yang
    • 1
  • Xiaoyu Zhao
    • 1
  • Wei Du
    • 1
  1. 1.Tianjin Key Laboratory of Marine Resources and Chemistry, College of Material Science and Chemical EngineeringTianjin University of Science and TechnologyTianjinPeople’s Republic of China

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