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Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells

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Abstract

Honokiol and magnolol, which are lignans isolated from Magnolia quinquepeta, have some pharmacological effects. However, the anti-inflammatory effects of honokiol and magnolol on periodontal disease are still uncertain. The aim of this study was to examine the effect of honokiol and magnolol on CXC chemokine receptor 3 (CXCR3) ligands, which are related with Th1 cell migration, production in interleukin (IL)-27-stimulated human oral epithelial cells (TR146 cells). Honokiol and magnolol inhibited CXC chemokine ligand (CXCL)10 and CXCL11 production in IL-27-stimulated TR146 cells in a dose-dependent manner. Moreover, we revealed that honokiol and magnolol could suppress signal transducer and activator of transcription (STAT)3 and protein kinase B (Akt) phosphorylation in IL-27-stimulated TR146 cells though STAT1 phosphorylation was not suppressed by honokiol and magnolol treatment. Furthermore, STAT3 and Akt inhibitors could suppress CXCR3 ligand production in TR146 cells. In summary, honokiol and magnolol could reduce CXCR3 ligand production in oral epithelial cell by inhibiting STAT3 and Akt activation.

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Funding

This work was supported by JSPS KAKENHI (Grant Numbers: 16K11834 and 18K09600).

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Authors and Affiliations

  1. Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, Tokushima, Japan

    Yoshitaka Hosokawa, Ikuko Hosokawa & Takashi Matsuo

  2. Department of Oral Health Care Promotion, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Tokushima, Japan

    Kazumi Ozaki

Authors
  1. Yoshitaka Hosokawa
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  2. Ikuko Hosokawa
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  3. Kazumi Ozaki
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  4. Takashi Matsuo
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Correspondence to Yoshitaka Hosokawa.

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Hosokawa, Y., Hosokawa, I., Ozaki, K. et al. Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells. Inflammation 41, 2110–2115 (2018). https://doi.org/10.1007/s10753-018-0854-z

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  • DOI: https://doi.org/10.1007/s10753-018-0854-z

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