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Acute Inflammation and Metabolism

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Abstract

Inflammation is an adaptive process to the noxious stimuli that the human body is constantly exposed to. From the local inflammatory response to a full-blown systemic inflammation, a wide complex sequence of events occurs. Persistent immunosuppression and catabolism may ensue, until multiple organ failure finally sets in. And since clinically useful and specific biomarkers are lacking, diagnosis may come late. A thorough understanding of these events (how they begin, how they evolve, and how to modulate them) is imperative, but as yet poorly studied. This review aims to consolidate current knowledge of these events so that the management of these patients is not only evidence-based, but also built on an understanding of the inner workings of the human body in health and in disease.

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Authors and Affiliations

  1. Internal Medicine 1, Hospital de Faro, Centro Hospitalar Universitário do Algarve, Rua Leão Penedo, Faro, 8000-386, Portugal

    Miguel Lourenço Varela, Mihail Mogildea, Ignacio Moreno & Ana Lopes

  2. Intensive Care Medicine 1, Hospital de Faro, Centro Hospitalar Universitário do Algarve, Rua Leão Penedo, Faro, 8000-386, Portugal

    Miguel Lourenço Varela

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  1. Miguel Lourenço Varela
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Correspondence to Miguel Lourenço Varela.

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Varela, M.L., Mogildea, M., Moreno, I. et al. Acute Inflammation and Metabolism. Inflammation 41, 1115–1127 (2018). https://doi.org/10.1007/s10753-018-0739-1

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