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Inflammation

, Volume 41, Issue 3, pp 751–759 | Cite as

FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation

  • Jun-yan Li
  • Nan Wang
  • Mir Hassan Khoso
  • Cheng-bin Shen
  • Meng-ze Guo
  • Xin-xin Pang
  • De-shan Li
  • Wen-fei Wang
ORIGINAL ARTICLE

Abstract

Fibroblast growth factor 21 (FGF-21) has been previously judged as a major metabolic regulator. In this paper, we show that FGF-21 has a potential role in anti-inflammation and immunoregulation. In vivo, treatment with exogenous FGF-21 can alleviate LPS-induced inflammation. In vitro, FGF-21 inhibited LPS-induced IL-1β expression in THP-1 cells. Furthermore, besides the NF-κB pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway. This study clearly indicates that FGF21 can be used as an attractive target for the management of inflammatory disorders. This piece of research indicates that FGF-21 could have much value in the management of inflammatory disorders.

KEY WORDS

FGF-21 THP-1 cells IL-10 LPS 

Notes

Funding Information

This study was funded by the “Young Talents” Project of Northeast Agricultural University (grant number 16QC27) and Natural Science Foundation of Heilongjiang Province of China (grant number C2017023).

Compliance with Ethical Standards

Ethics Statement

The study was approved by the Ethics Committee of Northeast Agricultural University.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Jun-yan Li
    • 1
  • Nan Wang
    • 1
  • Mir Hassan Khoso
    • 1
  • Cheng-bin Shen
    • 1
  • Meng-ze Guo
    • 1
  • Xin-xin Pang
    • 1
  • De-shan Li
    • 1
  • Wen-fei Wang
    • 2
  1. 1.Northeast Agricultural UniversitySchool of Life ScienceHarbinChina
  2. 2.Life Science and Biotechnique Research CenterA Division of Northeast Agricultural UniversityHarbinChina

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