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Inflammation

, Volume 41, Issue 2, pp 400–408 | Cite as

High Glucose Stimulates Expression of MFHAS1 to Mitigate Inflammation via Akt/HO-1 Pathway in Human Umbilical Vein Endothelial Cells

  • Hui-hui Wang
  • Peng-fei Sun
  • Wan-kun Chen
  • Jing Zhong
  • Qi-qing Shi
  • Mei-lin Weng
  • Duan Ma
  • Chang-hong Miao
ORIGINAL ARTICLE
  • 184 Downloads

Abstract

Hyperglycemia is a highly dangerous factor to various diseases, even resulting in death of people. Inflammation plays a key role in this process. The aim of this study was to explore the role of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) in high-glucose induced inflammation. Our research showed that high glucose stimulated the expression of MFHAS1, and overexpression of MFHAS1 can attenuate high-glucose induced inflammation in endothelial cells by decreasing the secretion of cytokines interleukin-1β (IL-1β), interleukin-1α (IL-1α), adhesion molecule intercellular adhesion molecule-1 (ICAM), interleukin-6 (IL-6), interleukin-8 (IL-8), and chemokine ligand 1 (CXCL-1). Furthermore, we found that MFHAS1 promoted the phosphorylation of Akt and the expression of heme oxygenase-1 (HO-1). Our results indicated that MFHAS1 deadened high-glucose induced inflammation by activating AKT/HO-1 pathway, suggesting that MFHAS1 may act as a new therapeutic target of diabetes mellitus.

KEY WORDS

high glucose inflammation MFHAS1 AKT HO-1 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81372101).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017
corrected publication December/2017

Authors and Affiliations

  • Hui-hui Wang
    • 1
  • Peng-fei Sun
    • 1
  • Wan-kun Chen
    • 1
  • Jing Zhong
    • 1
  • Qi-qing Shi
    • 2
  • Mei-lin Weng
    • 1
  • Duan Ma
    • 3
  • Chang-hong Miao
    • 1
  1. 1.Department of AnesthesiologyFudan University Shanghai Cancer CenterShanghaiChina
  2. 2.Children’s Hospital of Fudan UniversityShanghaiChina
  3. 3.Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Collaborative Innovation Center of Genetics and Development, Institute of Biomedical Sciences, School of Basic Medical SciencesFudan UniversityShanghaiChina

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