, Volume 40, Issue 1, pp 195–204 | Cite as

The Spatio-Temporal Expression Profiles of CD4 + T Cell Differentiation and Function-Related Genes During EAE Pathogenesis

  • Yingying Cai
  • Hu Shen
  • Chaoyan Qin
  • Jinfeng Zhou
  • Weiming Lai
  • Juping PanEmail author
  • Changsheng DuEmail author


Multiple sclerosis is a CD4+ T cell-mediated autoimmune disease of the central nervous system. The unbalance of the cytokines and transcription factors critical for CD4+ T cell differentiation and function is probably the main reason that causes MS. We detected the mRNA expression changes of key cytokines and transcription factors which are critical for Th1, Th2, Th17, and Treg cell differentiation and function in different tissues during EAE pathogenesis. We fund that each gene not only has its own featured expression changes, but also has interaction with one another, which composes a network of immunity. Understanding the roles of key cytokines and transcription factors in these processes will help to understand disease pathogenesis and supply indications for disease therapy.


cytokine experimental autoimmune encephalomyelitis multiple sclerosis transcription factor 



This work was supported by grants from the Ministry of Science and Technology of China (2014CB541903, 2012CB910404), the National Natural Science Foundation of China (31171348, 31371414), the Shanghai Municipal Education Commission (14zz042), the State Key Laboratory of Drug Research (SIMM1302KF-09), and the Fundamental Research Funds for the Central Universities.

Supplementary material

10753_2016_469_MOESM1_ESM.docx (119 kb)
Fig. S1 (DOCX 119 kb)


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Research Center for Translational Medicine at East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and TechnologyTongji UniversityShanghaiChina
  2. 2.Tongji Hospital of Tongji University BranchTongji UniversityShanghaiChina
  3. 3.State key Laboratory of Drug Research, Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina

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