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The Spatio-Temporal Expression Profiles of CD4 + T Cell Differentiation and Function-Related Genes During EAE Pathogenesis

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Abstract

Multiple sclerosis is a CD4+ T cell-mediated autoimmune disease of the central nervous system. The unbalance of the cytokines and transcription factors critical for CD4+ T cell differentiation and function is probably the main reason that causes MS. We detected the mRNA expression changes of key cytokines and transcription factors which are critical for Th1, Th2, Th17, and Treg cell differentiation and function in different tissues during EAE pathogenesis. We fund that each gene not only has its own featured expression changes, but also has interaction with one another, which composes a network of immunity. Understanding the roles of key cytokines and transcription factors in these processes will help to understand disease pathogenesis and supply indications for disease therapy.

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Acknowledgments

This work was supported by grants from the Ministry of Science and Technology of China (2014CB541903, 2012CB910404), the National Natural Science Foundation of China (31171348, 31371414), the Shanghai Municipal Education Commission (14zz042), the State Key Laboratory of Drug Research (SIMM1302KF-09), and the Fundamental Research Funds for the Central Universities.

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Authors and Affiliations

  1. Research Center for Translational Medicine at East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 1239 Si Ping Road, Shanghai, 200092, China

    Yingying Cai, Chaoyan Qin, Jinfeng Zhou, Weiming Lai & Changsheng Du

  2. Tongji Hospital of Tongji University Branch, Tongji University, 1239 Si Ping Road, Shanghai, 200092, China

    Hu Shen & Juping Pan

  3. State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

    Changsheng Du

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  1. Yingying Cai
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Correspondence to Juping Pan or Changsheng Du.

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Cai, Y., Shen, H., Qin, C. et al. The Spatio-Temporal Expression Profiles of CD4 + T Cell Differentiation and Function-Related Genes During EAE Pathogenesis. Inflammation 40, 195–204 (2017). https://doi.org/10.1007/s10753-016-0469-1

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