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Inflammation

, Volume 40, Issue 1, pp 324–327 | Cite as

Association of interleukin-18 and asthma

REVIEW

Abstract

Cytokine-mediated immunity plays a dominant role in the pathogenesis of various immune diseases, including asthma. The recent identification of the family interleukin (IL)-1-related cytokine IL-18 now contributes to our understanding of the fine-tuning of cellular immunity. IL-18 can act as a cofactor for Th2 cell development and IgE production and also plays an important role in the differentiation of Th1 cells. Recent work identified an IL-18 association with the pathogenesis of asthma, wherein increased IL-18 expression was found in the serum of patients. Furthermore, IL-18 polymorphisms with susceptibility to asthma were reported, suggesting that IL-18 may be therapeutically relevant to asthma. In this review, we discuss the role of IL-18 in the pathogenesis of asthma and its therapeutic potential based on current research.

KEY WORDS

IL-18 Asthma Th1 cell Th2 cell 

Notes

Acknowledgments

This work was supported by the Natural Science Foundation of China (81270011; 81472125).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of PediatricsThe Third Hospital Affiliated to Nantong UniversityWuxiChina

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