Effects of Acetylsalicylic Acid Usage on Inflammatory and Oxidative Stress Markers in Hemodialysis Patients
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The aims of this study were to determine the effects of acetylsalicylic acid (ASA) on inflammation and oxidative stress markers in hemodialysis (HD) patients and to examine the associations between these markers and the sociodemographic and clinical characteristics of participants. The study included 36 subjects who used 300 mg of ASA for 60 days. Inflammation and oxidative stress were assessed based on levels of biochemical markers. ASA usage promoted a decrease in high-sensitivity C-reactive protein (p = 0.01). The level of hydrogen peroxide increased after 30 days of use of ASA and subsequently decreased (p = 0.01). Reduced glutathione reduced at the end of the study (p < 0.01); the malondialdehyde level did not change and the levels of vitamins A and E were inverse to drug use (p = 0.01). ASA usage promoted reduced levels of inflammation, increased production of markers of oxidative stress, and reduced antioxidant defense.
KEY WORDShemodialysis acetylsalicylic acid inflammation oxidative stress antioxidant vitamins
We are grateful to Paula Garcia Chiarello, Alceu Afonso Jordão Júnior, and Paula Payão Ovidio for valuable discussions about this research, and we acknowledge financial support from CAPES-Brazil (Coordination for the Improvement of Higher Education Personnel—Brazil).
Conflict of Interest
The authors declare that they have no competing interests.
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